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Published, Version of Record (VoR)CC BY V4.0, Open
Journal article
Acetylation of the Cell-Fate Factor Dachshund Determines p53 Binding and Signaling Modules in Breast Cancer
Oncotarget, v 4(6), pp 923-935
21 Jun 2013
PMID: 23798621
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Breast cancer is a leading form of cancer in the world. The
Drosophila Dac
gene was cloned as an inhibitor of the hyperactive epidermal growth factor (EGFR),
ellipse
. Herein, endogenous DACH1 co-localized with p53 in a nuclear, extranucleolar compartment and bound to p53 in human breast cancer cell lines, p53 and DACH1 bound common genes in Chip-Seq. Full inhibition of breast cancer contact-independent growth by DACH1 required p53. The p53 breast cancer mutants R248Q and R273H, evaded DACH1 binding. DACH1 phosphorylation at serine residue (S439) inhibited p53 binding and phosphorylation at p53 amino-terminal sites (S15, S20) enhanced DACH1 binding. DACH1 binding to p53 was inhibited by NAD-dependent deacetylation via DACH1 K628. DACH1 repressed p21
CIP1
and induced RAD51, an association found in basal breast cancer. DACH1 inhibits breast cancer cellular growth in an NAD and p53-dependent manner through direct protein-protein association.
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Details
- Title
- Acetylation of the Cell-Fate Factor Dachshund Determines p53 Binding and Signaling Modules in Breast Cancer
- Creators
- Ke Chen - Thomas Jefferson UniversityKongming Wu - Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA Proteomics Resource Center, Rockefeller University, New York, NY, USAMichael Gormley - Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA Proteomics Resource Center, Rockefeller University, New York, NY, USAAdam Ertel - Thomas Jefferson UniversityJing Wang - Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA Proteomics Resource Center, Rockefeller University, New York, NY, USAWei Zhang - Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA Proteomics Resource Center, Rockefeller University, New York, NY, USAJie Zhou - Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA Proteomics Resource Center, Rockefeller University, New York, NY, USAGabriele DiSante - Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA Proteomics Resource Center, Rockefeller University, New York, NY, USAZhiping Li - Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA Proteomics Resource Center, Rockefeller University, New York, NY, USAHallgeir Rui - Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA Proteomics Resource Center, Rockefeller University, New York, NY, USAAndrew A. Quong - Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA Proteomics Resource Center, Rockefeller University, New York, NY, USASteven B. McMahon - Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA Proteomics Resource Center, Rockefeller University, New York, NY, USAHaiteng Deng - Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA Proteomics Resource Center, Rockefeller University, New York, NY, USAMichael P. Lisanti - Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA Proteomics Resource Center, Rockefeller University, New York, NY, USAChenguang Wang - Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA Proteomics Resource Center, Rockefeller University, New York, NY, USARichard G. Pestell - Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA, USA Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA Proteomics Resource Center, Rockefeller University, New York, NY, USA
- Publication Details
- Oncotarget, v 4(6), pp 923-935
- Publisher
- Impact Journals LLC
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000322580700017
- Scopus ID
- 2-s2.0-84880830761
- Other Identifier
- 991019176798104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cell Biology
- Oncology