Journal article
Acoustic Parameters for Optimal Ultrasound-Triggered Release from Novel Spinal Hardware Devices
Ultrasound in medicine & biology, v 46(2), pp 350-358
Feb 2020
PMID: 31732196
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Post-operative infection is a catastrophic complication of spinal fusion surgery, with rates as high as 10%, and existing preventative measures (i.e., peri-operative antibiotics) are only partially successful. To combat this clinical problem, we have designed a drug delivery system around polyether ether ketone clips to be used for prophylactic post-surgical release of antibiotics upon application of ultrasound. The overall hypothesis is that antimicrobial release from this system will aggressively combat post-surgical bacterial survival. This study investigated a set of acoustic parameters optimized for in vitro ultrasound-triggered coating rupture and subsequent release of encapsulated prophylactic antibiotics. We determined that a transducer frequency of 1.7 MHz produced the most consistent burst release and that, at this frequency, a pulse repetition frequency of 6.4 kHz and acoustic output power of 100% (3.41 MPa) produced the greatest release, representing an important proof of principle and the basis for continued development of this novel drug delivery system.
Metrics
Details
- Title
- Acoustic Parameters for Optimal Ultrasound-Triggered Release from Novel Spinal Hardware Devices
- Creators
- Lauren J. Delaney - Department of Radiology, Thomas Jefferson University, Philadelphia, Pennsylvania, USACemile Basgul - Drexel UniversityDaniel W. MacDonald - Drexel UniversityKeith Fitzgerald - Thomas Jefferson UniversityNoreen J. Hickok - Thomas Jefferson UniversitySteven M. Kurtz - Exponent (United States)Flemming Forsberg - Thomas Jefferson University
- Publication Details
- Ultrasound in medicine & biology, v 46(2), pp 350-358
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000503830700016
- Scopus ID
- 2-s2.0-85075453305
- Other Identifier
- 991019168026004721
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InCites Highlights
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Acoustics
- Radiology, Nuclear Medicine & Medical Imaging