Journal article
Action of potassium on neurochemical transmission at the cardiac adrenergic neuroeffector junction with aging
Mechanisms of ageing and development, v 52(1), pp 87-91
1990
PMID: 2314130
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The effect of age on potassium (K
+)-induced norepinephrine release in the heart was studied in 6- and 24-month-old male Fischer-344 rats. Isolated hearts were perfused with Krebs-Ringer solution according to Langendorff method. K
+ was employed as 2 ml bolus at the concentrtions of 70, 90, 100 and 120 μM. Norepinephrine content was measured by high pressure liquid-chromatography/electrochemical detection methodology. At each of the K
− concentrations, the amount of norepinephrine released from preparations of 6-month-old animals was significantly greater than observed from preparations of 24-month-old animals. Since K
+-induced release of norepinephrine is associated with calcium influx, the decrease in the capacity of K
+ to cause norepinephrine release with age supports the hypothesis that diminution in transmitter release is due to altered calcium function.
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Details
- Title
- Action of potassium on neurochemical transmission at the cardiac adrenergic neuroeffector junction with aging
- Creators
- Nihal Tumer - Drexel UniversityPatrick J. Ryan - Drexel UniversityJay Roberts - Drexel UniversityJames R Roberts - Emergency Medicine
- Publication Details
- Mechanisms of ageing and development, v 52(1), pp 87-91
- Publisher
- Elsevier Ireland Ltd
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Emergency Medicine
- Web of Science ID
- WOS:A1990CQ41900008
- Scopus ID
- 2-s2.0-0025191015
- Other Identifier
- 991019184017504721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cell Biology
- Geriatrics & Gerontology