Journal article
Activated Ras enhances insulin-like growth factor I induction of vascular endothelial growth factor in prostate epithelial cells
Cancer research (Chicago, Ill.), v 65(6), pp 2085-2088
15 Mar 2005
PMID: 15781617
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Mutations in the three closely related RAS genes, HRAS, KRAS, and NRAS are among the most common mutations found in human cancer; reaching 50% in some types of cancer, such as colorectal carcinoma, and 10% in prostate cancers. The activated Ras proteins produced by these mutations can, among other cellular changes, increase vascular endothelial growth factor (VEGF) production. Moreover, tumors bearing RAS gene mutations are more vascular than tumors without RAS mutations. We find that, in prostate epithelial cells, the introduction of an activated HRAS causes cells to produce VEGF in response to insulin-like growth factor I (IGF-I). In comparison, cells lacking an activated Ras are unable to produce VEGF in response to IGF-I. This effect of Ras may occur through stabilization of a second messenger protein, insulin receptor substrate 1, that mediates PI 3-kinase-dependent signaling. Because IGF-I is a paracrine/endocrine hormone that has been associated with increased risk for several types of cancer, these results suggest a novel interrelationship between oncogenic conversion of a cellular gene such as HRAS, and IGF-I produced locally for normal tissue homeostasis.
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Details
- Title
- Activated Ras enhances insulin-like growth factor I induction of vascular endothelial growth factor in prostate epithelial cells
- Creators
- Mark Stearns - Drexel UniversityJordan TranMary Kay FrancisHong ZhangChristian SellHua Zhang - Electrical and Computer Engineering
- Publication Details
- Cancer research (Chicago, Ill.), v 65(6), pp 2085-2088
- Publisher
- American Association for Cancer Research (AACR)
- Grant note
- CA 76639-07 / NCI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology; Electrical and Computer Engineering
- Web of Science ID
- WOS:000227600000008
- Scopus ID
- 2-s2.0-16844381319
- Other Identifier
- 991019168049504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Oncology