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Activation of NF-κB in Schwann Cells Is Dispensable for Myelination In Vivo
Journal article   Open access   Peer reviewed

Activation of NF-κB in Schwann Cells Is Dispensable for Myelination In Vivo

Paul D. Morton, Anna Dellarole, Michelle H. Theus, Winston M. Walters, Summer S. Berge and John R. Bethea
The Journal of neuroscience, v 33(24), pp 9932-9936
12 Jun 2013
PMID: 23761888
url
https://www.jneurosci.org/content/jneuro/33/24/9932.full.pdfView
Published, Version of Record (VoR) Open
url
https://doi.org/10.1523/JNEUROSCI.2483-12.2013View
Published, Version of Record (VoR) Open

Abstract

Brief Communications
Peripheral myelination is a dynamic process orchestrated by axons and Schwann cells. Although the signaling mechanisms governing myelination are not fully understood, NF-κB activation in Schwann cells has been implicated as a key regulator in vitro . Using a mouse model, we show that nuclear factor κB activation in Schwann cells is not required for myelination in vivo .

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