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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Activation of Phase Change Contrast Agents Using Ionizing Radiation
JOURNAL OF ULTRASOUND IN MEDICINE, v 41(9), pp 2365-2371
Sep 2022
PMID: 34866197
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The feasibility of activating phase change contrast agents (PCCA) made from Definity (Lantheus Medical Imaging) using X-rays was investigated. A 10 mL of Definity PCCA (0.1 mL PCCA/mL) were injected into gelatin phantoms and irradiated using doses of 0, 30, 50, and 100 Gy. Size distribution and PCCA activation were measured after irradiation. Definity PCCAs were activated at a threshold of 50 Gy. Changes were visible with microscopy, visual inspection of T-flasks, and ultrasound imaging of gelatin phantoms. Moreover, increasing the radiation dose above 50 Gy appeared to further activate PCCA. These results indicate Definity PCCAs may be useful for ultrasound-based radiation dosimetry.
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Details
- Title
- Activation of Phase Change Contrast Agents Using Ionizing Radiation
- Publication Details
- JOURNAL OF ULTRASOUND IN MEDICINE, v 41(9), pp 2365-2371
- Publisher
- WILEY; HOBOKEN
- Number of pages
- 6
- Grant note
- Funding for this work was provided in part by the United States National Institute of Health grants R01 EB26881 and R01 CA238241. The first author would like to acknowledge the support of a scholarship from King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia. The authors extended their appreciation to Drs. Paul Dayton, Virginie Papadopoulou, and Phillip Durham at the University of North Carolina, Chapel Hill for their helpful guidance and feedback on fabricating Definity droplets and gelatin phantoms.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:000726567300001
- Scopus ID
- 2-s2.0-85120905764
- Other Identifier
- 991021860665304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Acoustics
- Radiology, Nuclear Medicine & Medical Imaging