Journal article
Activation of anti-apoptotic protein survivin upon JCV infection in glial cells. Implications for the development of progressive multifocal leukoencephalopathy
Journal of neurovirology, Vol.13, pp.113-113
01 Jan 2007
Abstract
Progressive Multifocal Leukoencephalopathy (PML) is a sub-acute and fatal disease of the Central Nervous System, result of the productive infection of glial cells, particularly oligodendrocytes, by the opportunistic JC Virus. The lytic destruction of oligodendrocytes and the activation of astrocytes in response to JCV infection results in the characteristic histopathological land-marks of PML; extensive and confluent areas of myelin loss, in which numerous bizarre reactive astrocytes with atypical and pleomorphic nuclei, and enlarged oligodendrocytes harboring intra-nuclear eosinophilic inclusion bodies, which represent the site of active viral replication.
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Details
- Title
- Activation of anti-apoptotic protein survivin upon JCV infection in glial cells. Implications for the development of progressive multifocal leukoencephalopathy
- Creators
- S Pina-OviedoK UrbanskaT SweetK ReissK KhaliliL Del Valle
- Publication Details
- Journal of neurovirology, Vol.13, pp.113-113
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Identifiers
- 991021448179104721