Journal article
Activation of cPLA(2) in vascular smooth muscle
Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, v 4, pp 177-182
01 Jan 1999
PMID: 10667328
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Force regulation in vascular smooth muscle is under the control of a variety of lipid-dependent second messengers, such as inositol 1,4,5 trisphosphate and diacylglycerol (Hashimoto et al.,1986; Gu et al., 1991). Our laboratory has demonstrated that norepinephrine can induce force in rat tail artery via the stimulation of IP3 production and the resulting release of calcium ions from intracellular stores (Gu et al.,1991; Somlyo et al,1985). It appears that IP3 production in this tissue is under the control of a G-protein-dependent isoform of phospholipase C known as phospholipase Cb2 (LaBelle and Murray, 1990; LaBelle and Polyak,1996). We have also demonstrated that norepinephrine can activate phospholipase D in rat tail artery, with the resulting production of choline and phosphatidic acid from the lipid phosphatidylcholine (Gu et al, 1992).
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Details
- Title
- Activation of cPLA(2) in vascular smooth muscle
- Creators
- Edward F LaBelle - Drexel University, Allegheny University of the Health Sciences (1996-1998)Erzsebet Polyak - Drexel University, Allegheny University of the Health Sciences (1996-1998)
- Contributors
- Kenneth V Honn (Editor) - Wayne State UniversityLawrence J Marnett (Editor) - Vanderbilt University School of MedicineSantosh Nigam (Editor) - Freie Universität BerlinEdward A Dennis (Editor) - University of California San Diego
- Publication Details
- Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury, v 4, pp 177-182
- Series
- Advances in Experimental Medicine and Biology; 469
- Publisher
- KLUWER ACADEMIC / PLENUM PUBL
- Number of pages
- 6
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000085570100027
- Scopus ID
- 2-s2.0-0033250309
- Other Identifier
- 991019168812404721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Cell Biology
- Medicine, Research & Experimental