Journal article
Activity-Dependent Changes in Extracellular Ca2+ and K+ Reveal Pacemakers in the Spinal Locomotor-Related Network
Neuron (Cambridge, Mass.), v 77(6), pp 1047-1054
20 Mar 2013
PMID: 23522041
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Changes in the extracellular ionic concentrations occur as a natural consequence of firing activity in large populations of neurons. The extent to which these changes alter the properties of individual neurons and the operation of neuronal networks remains unknown. Here, we show that the locomotor-like activity in the isolated neonatal rodent spinal cord reduces the extracellular calcium ([Ca2+]o) to 0.9 mM and increases the extracellular potassium ([K+]o) to 6 mM. Such changes in [Ca2+]o and [K+]o trigger pacemaker activities in interneurons considered to be part of the locomotor network. Experimental data and a modeling study show that the emergence of pacemaker properties critically involves a [Ca2+]o-dependent activation of the persistent sodium current (INaP). These results support a concept for locomotor rhythm generation in which INaP-dependent pacemaker properties in spinal interneurons are switched on and tuned by activity-dependent changes in [Ca2+]o and [K+]o.
► Steady-state [Ca2+]o and [K+]o in the locomotor network change during locomotion ► [Ca2+]o and [K+]o start to change before the onset of locomotion ► Changes in [Ca2+]o and [K+]o trigger pacemaker properties in interneurons ► Pacemaker properties result from an upregulation of the persistent sodium current
The mechanisms involved in the generation of the locomotor rhythm remain largely unknown. Brocard et al. find that pacemaker interneurons whose properties are switched on and tuned by network activity-dependent changes in extracellular Ca2+ and K+ play a central role.
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Details
- Title
- Activity-Dependent Changes in Extracellular Ca2+ and K+ Reveal Pacemakers in the Spinal Locomotor-Related Network
- Creators
- Frédéric Brocard - Team P3M, Institut de Neurosciences de la Timone, UMR 7289, CNRS and Aix-Marseille Université, F-13385 Marseille, FranceNatalia A Shevtsova - Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USAMouloud Bouhadfane - Team P3M, Institut de Neurosciences de la Timone, UMR 7289, CNRS and Aix-Marseille Université, F-13385 Marseille, FranceSabrina Tazerart - Team P3M, Institut de Neurosciences de la Timone, UMR 7289, CNRS and Aix-Marseille Université, F-13385 Marseille, FranceUwe Heinemann - Neurowissenschaftliches Forschungszentrum und Institut für Neurophysiologie, Charité Universitätsmedizin Berlin Garystrasse 5, 14195 Berlin, GermanyIlya A Rybak - Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USALaurent Vinay - Team P3M, Institut de Neurosciences de la Timone, UMR 7289, CNRS and Aix-Marseille Université, F-13385 Marseille, France
- Publication Details
- Neuron (Cambridge, Mass.), v 77(6), pp 1047-1054
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000316645000007
- Scopus ID
- 2-s2.0-84875484864
- Other Identifier
- 991014877815004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences