Journal article
Acute Portal Hypertension Models in Dogs Low- and High-Flow Approaches
Comparative medicine, v 62(5), pp 419-426
01 Oct 2012
PMID: 23114046
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Effective animal models are needed to evaluate the feasibility of new techniques to assess portal hypertension (PH). Here we developed 2 canine models of acute PH by increasing intrasinusoidal resistance and by increasing the portal vein (PV) flow volume to test the efficacy of a noninvasive technique to evaluate PH. The acute low-flow PH model was based on embolization of liver circulation by using a gelatin sponge material. The acute high-flow PH model was based on increasing the PV flow volume by using an arteriovenous (A-V) shunt from the femoral artery and saline infusion. PV pressures and diameters were assessed before and after inducing PH. Pressure values and diameters were obtained from the inferior vena cava in 3 unmanipulated controls. The low-flow model of PH was repeatable and successfully increased PV pressure by an average of 16.5 mm Hg within 15 min. The high-flow model of PH failed to achieve increased PV pressures. However, saline supplementation of the portal circulation in the high-flow model led to mean increases in PV pressures of 12.8 mm Hg within 20 min. Pulsatility in the PV was decreased in the low-flow model and increased in the high-flow model relative to baseline. No changes in PV diameter were noted in either model. These acute PH models are relatively straightforward to implement and may facilitate the evaluation of new techniques to assess PH.
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Details
- Title
- Acute Portal Hypertension Models in Dogs Low- and High-Flow Approaches
- Creators
- Jaydev K. Dave - Thomas Jefferson UniversityJi-Bin Liu - Thomas Jefferson UniversityValgerdur G. Halldorsdottir - Thomas Jefferson UniversityJohn R. Eisenbrey - Thomas Jefferson UniversityDaniel A. Merton - Thomas Jefferson UniversityPriscilla Machado - Thomas Jefferson UniversityHongjia Zhao - Thomas Jefferson UniversityJoseph Altemus - Thomas Jefferson UniversityLaurence Needleman - Thomas Jefferson UniversityDaniel B. Brown - Thomas Jefferson UniversityFlemming Forsberg - Thomas Jefferson University
- Publication Details
- Comparative medicine, v 62(5), pp 419-426
- Publisher
- Amer Assoc Laboratory Animal Science
- Number of pages
- 8
- Grant note
- RC1DK087365 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) R21HL081892 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) W81XWH-08-1-0503 / US Army Medical Research and Material Command; U.S. Army Medical Research & Materiel Command (USAMRMC) R21 HL081892; RC1 DK087365 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000309797100009
- Scopus ID
- 2-s2.0-84870934650
- Other Identifier
- 991019350686204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Veterinary Sciences
- Zoology