Journal article
Acute anticonvulsant effects of capric acid in seizure tests in mice
Progress in neuro-psychopharmacology & biological psychiatry, v 57, pp 110-116
03 Mar 2015
PMID: 25445478
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Capric acid (CA10) is a 10-carbon medium-chain fatty acid abundant in the medium-chain triglyceride ketogenic diet (MCT KD). The purpose of this study was to characterize acute anticonvulsant effects of CA10 across several seizure tests in mice. Anticonvulsant effects of orally (p.o.) administered CA10 were assessed in the maximal electroshock seizure threshold (MEST), 6-Hz seizure threshold, and intravenous pentylenetetrazole (i.v. PTZ) seizure tests in mice. Acute effects of CA10 on motor coordination were assessed in the grip and chimney tests. Plasma and brain concentrations of CA10 were measured. Co-administration studies with CA10 and another abundant medium-chain fatty acid, caprylic acid (CA8) were performed. CA10 showed significant and dose-dependent anticonvulsant properties by increasing seizure thresholds in the 6-Hz and MEST seizure tests; it was ineffective in the i. v. PTZ seizure test. At higher doses than those effective in the 6-Hz and MEST seizure tests, CA10 impaired motor performance in the grip and chimney tests. An enhanced anticonvulsant response in the 6-Hz seizure test was produced when CA8 and CA10 were co-administered. An acute p. o. administration of CA10 resulted in dose-proportional increases in its plasma and brain concentrations. CA10 exerted acute anticonvulsant effects at doses that produce plasma exposures comparable to those reported in epileptic patients on the MCT KD. An enhanced anticonvulsant effect is observed when CA10 and the other main constituent of the MCT KD, CA8, were co-administered. Thus, acute anticonvulsant properties of CA10 and CA8 may influence the overall clinical efficacy of the MCT KD. (C) 2014 Elsevier Inc. All rights reserved.
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Details
- Title
- Acute anticonvulsant effects of capric acid in seizure tests in mice
- Creators
- Piotr Wlaz - Maria Curie-Skłodowska UniversityKatarzyna Socala - Marie Curie Sklodowska Univ, Inst Biol & Biochem, Dept Anim Physiol, Lublin, PolandDorota Nieoczym - Maria Curie-Skłodowska UniversityTomasz Zarnowski - Medical University of LublinIwona Zarnowska - Medical University of LublinStanislaw J. Czuczwar - Med Univ, Dept Pathophysiol, Lublin, PolandMaciej Gasior - Drexel University
- Publication Details
- Progress in neuro-psychopharmacology & biological psychiatry, v 57, pp 110-116
- Publisher
- Elsevier
- Number of pages
- 7
- Grant note
- Funds for Statutory Activity of Maria Curie-Sklodowska University, Lublin and Medical University of Lublin, Poland
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000346057800014
- Scopus ID
- 2-s2.0-84911441209
- Other Identifier
- 991019168428604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Clinical Neurology
- Neurosciences
- Pharmacology & Pharmacy
- Psychiatry