Journal article
Acute effect of substance P in immunologic vasculitis in the rat colon
Peptides (New York, N.Y. : 1980), v 12(6), pp 1337-1345
1991
PMID: 1726122
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Abstract
Substance P has been implicated as a neuronal mediator of inflammation in various inflammatory conditions. However, the exact role played by substance P in inflammatory bowel diseases or in experimental colonic vasculitis has not been clearly understood. In this study, we examined the effect of close superior mesenteric artery injection of substance P under prevailing inflammatory conditions induced by intravenous human albumin antialbumin immune complex followed by intracolonic perfusion of 2.5% formaldehyde in rats or intracolonic perfusion of 5% alcohol alone. The immune complex- and formaldehyde-treated rats showed severe microvascular changes such as microvascular plugging by red blood cells, endothelial breakage and extravasation of plasma proteins and red blood cells. The bolus injection of 10
−8 M substance P reduced extravasation of Evans blue dye by 50% and the tissue wet to dry ratio by 20% in immune complex- and formaldehyde-perfused rats. Myeloperoxidase activity was not changed. Substance P also significantly inhibited (44%) the extravasation in alcohol-perfused rats. Pretreatment of immune complex- and formaldehyde-treated rats with substance P antagonist reversed the effect of substance P. These findings suggest that the most immediate effect of substance P may be vasodilation and clearing of vascular plugs induced by immune complex and formaldehyde. This effect of substance P differs from its chronic effect, which causes vasodilation and extravasation.
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Details
- Title
- Acute effect of substance P in immunologic vasculitis in the rat colon
- Creators
- S.N.S. Murthy - Krancer Center for Inflammatory Bowel Diseases, Division of Gastroenterology USADennis M. DePace - Department of Anatomy USARupal S. Shah - Krancer Center for Inflammatory Bowel Diseases, Division of Gastroenterology USARoss Podell - Krancer Center for Inflammatory Bowel Diseases, Division of Gastroenterology USA
- Publication Details
- Peptides (New York, N.Y. : 1980), v 12(6), pp 1337-1345
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:A1991GW10100028
- Scopus ID
- 2-s2.0-0026347899
- Other Identifier
- 991019184080004721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Endocrinology & Metabolism
- Pharmacology & Pharmacy