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Acute mechanical effects of elastase on the infrarenal mouse aorta: Implications for models of aneurysms
Journal article   Open access   Peer reviewed

Acute mechanical effects of elastase on the infrarenal mouse aorta: Implications for models of aneurysms

M. J. Collins, J. F. Eberth, E. Wilson and J. D. Humphrey
Journal of biomechanics, v 45(4), pp 660-665
23 Feb 2012
DOI: https://doi.org/10.1016/j.jbiomech.2011.12.013
PMID: 22236532
url
https://europepmc.org/articles/pmc3328218View
Accepted (AM)Open Access (License Unspecified),  Open

Abstract

Biophysics Engineering Engineering, Biomedical Life Sciences & Biomedicine Science & Technology Technology
Intraluminal exposure of the infrarenal aorta to porcine pancreatic elastase represents one of the most commonly used experimental models of the development and progression of abdominal aortic aneurysms. Morphological and histological effects of elastase on the aortic wall have been well documented in multiple rodent models, but there has been little attention to the associated effects on mechanical properties. In this paper, we present the first biaxial mechanical data on, and associated nonlinear constitutive descriptors of, the effects of elastase on the infrarenal aorta in mice. Quantification of the dramatic, acute effects of elastase on wall behavior in vitro is an essential first step toward understanding the growth and remodeling of aneurysms in vivo, which depends on both the initial changes in the mechanics and the subsequent inflammation-mediated turnover of cells and extracellular matrix that contributes to the evolving mechanics. (C) 2011 Elsevier Ltd. All rights reserved.

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36 citations in Web of Science
35 citations in Scopus

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Collaboration types
Domestic collaboration
Web of Science research areas
Biophysics
Engineering, Biomedical
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