Journal article
Acute myocardial infarction and antiphospholipid antibody syndrome: A systematic review
Coronary artery disease, v 28(4), pp 332-335
01 Jun 2017
PMID: 28225386
Abstract
Background
Antiphospholipid antibody syndrome (APS) is a disorder associated with both arterial and venous thromboembolic disease, including acute myocardial infarction (AMI). Given that management with anticoagulants is critical and differs from usual AMI care, identification of key discriminators of patients with AMI with APS is important.
Methods
We performed an English-language systematic review of the literature of cases and case series of patients with AMI and APS from inception until 20 March 2016, collecting demographics, investigations, and outcomes.
Results
Forty cases of AMI because of APS were identified from 27 articles. Patients were younger than typical AMI patients (41.10±13.61 years) and 45% were women. STelevation myocardial infarction was the presentation in 45% (18/40) of cases. The average platelet count was 130 000±138 912 c/mm3 in the 10 cases reporting it and partial thromboplastin time was elevated in all four reporting it. Coronary arteries were described as normal or with acute thrombosis in 75%. Three died during hospitalization and six had recurrence of myocardial infarction within 3 months after admission.
Conclusion
APS should be considered in young patients with AMI, especially if previous unprovoked thromboses, lower platelet counts, high partial thromboplastin times, and normal coronary arteries or coronary thromboses are identified.
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Details
- Title
- Acute myocardial infarction and antiphospholipid antibody syndrome: A systematic review
- Creators
- Salik Nazir - Reading HospitalNiranjan Tachamo - Reading HospitalSaroj Lohani - Reading HospitalRittu Hingorani - Thomas Jefferson UniversityDilli R. Poudel - Reading HospitalAnthony Donato - Thomas Jefferson University
- Publication Details
- Coronary artery disease, v 28(4), pp 332-335
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 4
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Medicine (Graduate); General Internal Medicine
- Web of Science ID
- WOS:000400500500010
- Scopus ID
- 2-s2.0-85013436225
- Other Identifier
- 991022161840504721