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Acute myocardial infarction and antiphospholipid antibody syndrome: A systematic review
Journal article   Peer reviewed

Acute myocardial infarction and antiphospholipid antibody syndrome: A systematic review

Salik Nazir, Niranjan Tachamo, Saroj Lohani, Rittu Hingorani, Dilli R. Poudel and Anthony Donato
Coronary artery disease, v 28(4), pp 332-335
01 Jun 2017
DOI: https://doi.org/10.1097/MCA.0000000000000476
PMID: 28225386
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

acute myocardial infarction anticoagulation antiphospholipid syndrome
Background Antiphospholipid antibody syndrome (APS) is a disorder associated with both arterial and venous thromboembolic disease, including acute myocardial infarction (AMI). Given that management with anticoagulants is critical and differs from usual AMI care, identification of key discriminators of patients with AMI with APS is important. Methods We performed an English-language systematic review of the literature of cases and case series of patients with AMI and APS from inception until 20 March 2016, collecting demographics, investigations, and outcomes. Results Forty cases of AMI because of APS were identified from 27 articles. Patients were younger than typical AMI patients (41.10±13.61 years) and 45% were women. STelevation myocardial infarction was the presentation in 45% (18/40) of cases. The average platelet count was 130 000±138 912 c/mm3 in the 10 cases reporting it and partial thromboplastin time was elevated in all four reporting it. Coronary arteries were described as normal or with acute thrombosis in 75%. Three died during hospitalization and six had recurrence of myocardial infarction within 3 months after admission. Conclusion APS should be considered in young patients with AMI, especially if previous unprovoked thromboses, lower platelet counts, high partial thromboplastin times, and normal coronary arteries or coronary thromboses are identified.

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Collaboration types
International collaboration
Web of Science research areas
Cardiac & Cardiovascular Systems
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