Journal article
Acute rheumatic fever and streptococci: the quintessential pathogenic trigger of autoimmunity
Clinical rheumatology, v 33(7), pp 893-901
01 Jul 2014
PMID: 24894108
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Acute rheumatic fever (ARF) is a non-suppurative complication of pharyngeal infection with group A streptococcus. Signs and symptoms of ARF develop 2 to 3 weeks following pharyngitis and include arthritis, carditis, chorea, subcutaneous nodules, and erythema marginatum. In developing areas of the world, ARF and rheumatic heart disease are estimated to affect nearly 20 million people and remain leading causes of cardiovascular death during the first five decades of life. ARF still represents one of the quintessential examples of a pathogenic trigger culminating in autoimmune manifestations. In this review, we will focus on the pathogenesis and etiology of ARF and its complications, along with diagnostic and treatment approaches to both ameliorate and prevent long-term sequelae of this potentially debilitating disease.
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Details
- Title
- Acute rheumatic fever and streptococci: the quintessential pathogenic trigger of autoimmunity
- Creators
- Soumya D. Chakravarty - Cornell UniversityJohn B. Zabriskie - Rockefeller UniversityAllan Gibofsky - Cornell University
- Publication Details
- Clinical rheumatology, v 33(7), pp 893-901
- Publisher
- Springer Nature
- Number of pages
- 9
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Rheumatology; General Internal Medicine
- Web of Science ID
- WOS:000338324000003
- Scopus ID
- 2-s2.0-84903521313
- Other Identifier
- 991021930316404721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Rheumatology