Journal article
Adaptation of Thalamic Neurons Provides Information about the Spatiotemporal Context of Stimulus History
The Journal of neuroscience, v 37(41), pp 10012-10021
11 Oct 2017
PMID: 28899918
Abstract
Adaptation of neural responses due to the history of sensory input has been observed across all sensory modalities. However, the computational role of adaptation is not fully understood, especially when one considers neural coding problems in which adaptation increases the ambiguity of the neural responses to simple stimuli. To address this, we quantified the impact of adaptation on the information conveyed by thalamic neurons about paired whisker stimuli in male rat. At the single neuron level, although paired-pulse adaptation reduces the information about the present stimulus, the information per spike increases. Moreover, the adapted response can convey significant amounts of information about whether, when and where a previous stimulus occurred. At the population level, ambiguity of the adapted responses about the present stimulus can be compensated for by large numbers of neurons. Therefore, paired-pulse adaptation does not reduce the discriminability of simple stimuli. It provides information about the spatiotemporal context of stimulus history.
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Details
- Title
- Adaptation of Thalamic Neurons Provides Information about the Spatiotemporal Context of Stimulus History
- Creators
- Chen Liu - Drexel UniversityGuglielmo Foffani - CEU San Pablo UniversityAlessandro Scaglione - Drexel UniversityJuan Aguilar - Hospital Nacional de Parapléjicos de ToledoKaren A. Moxon - Drexel University
- Publication Details
- The Journal of neuroscience, v 37(41), pp 10012-10021
- Publisher
- Soc Neuroscience
- Number of pages
- 10
- Grant note
- R01NS096971 / National Institute of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA CBET-1402984 / National Science Foundation; National Science Foundation (NSF) 89500 / Shriners Hospital for Children R01NS096971 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000412800500018
- Scopus ID
- 2-s2.0-85031696410
- Other Identifier
- 991019168222704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences