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Journal article
Adapting Human-Based Transcutaneous Spinal Cord Stimulation to Develop a Clinically Relevant Animal Model
Journal of clinical medicine, v 11(7), p2023
01 Apr 2022
PMID: 35407636
Featured in Collection : Research Supported by Drexel Libraries' OA Programs
Abstract
Transcutaneous spinal cord stimulation (tSCS) as a neuromodulatory strategy has received great attention as a method to promote functional recovery after spinal cord injury (SCI). However, due to the noninvasive nature of tSCS, investigations have primarily focused on human applications. This leaves a critical need for the development of a suitable animal model to further our understanding of this therapeutic intervention in terms of functional and neuroanatomical plasticity and to optimize stimulation protocols. The objective of this study is to establish a new animal model of thoracolumbar tSCS that (1) can accurately recapitulate studies in healthy humans and (2) can receive a repeated and stable tSCS treatment after SCI with minimal restraint, while the electrode remains consistently positioned. We show that our model displays bilateral evoked potentials in multisegmental leg muscles characteristically comparable to humans. Our data also suggest that tSCS mainly activates dorsal root structures like in humans, thereby accounting for the different electrode-to-body-size ratio between the two species. Finally, a repeated tSCS treatment protocol in the awake rat after a complete spinal cord transection is feasible, tolerable, and safe, even with minimal body restraint. Additionally, repeated tSCS was capable of modulating motor output after SCI, providing an avenue to further investigate stimulation-based neuroplasticity and optimize treatment.
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Details
- Title
- Adapting Human-Based Transcutaneous Spinal Cord Stimulation to Develop a Clinically Relevant Animal Model
- Creators
- Dillon C. Malloy - Drexel UniversityMaria Knikou - College of Staten IslandMarie-Pascale Cote - Drexel University
- Publication Details
- Journal of clinical medicine, v 11(7), p2023
- Publisher
- Mdpi
- Number of pages
- 16
- Grant note
- 647897 / Craig H. Neilsen Foundation RO1 NS119475 / National Institute of Neurological Disorders; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) 647897 / New York State Department of Health (NYSDOH), Spinal Cord Injury Research Program (SCIRP) RO1 HD100544 / National Institute of Child Health and Human Development; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) Drexel University Libraries Open Access Publishing Fund
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000781373700001
- Scopus ID
- 2-s2.0-85127585720
- Other Identifier
- 991019168587304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences