Journal article
Adaptive Evolution and Effective Population Size in Wild House Mice
Molecular biology and evolution, v 29(10), pp 2949-2955
01 Oct 2012
PMID: 22490822
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Estimates of the proportion of amino acid substitutions that have been fixed by selection (a) vary widely among taxa, ranging from zero in humans to over 50% in Drosophila. This wide range may reflect differences in the efficacy of selection due to differences in the effective population size (N e). However, most comparisons have been made among distantly related organisms that differ not only in N e but also in many other aspects of their biology. Here, we estimate a in three closely related lineages of house mice that have a similar ecology but differ widely in N e : Mus musculus musculus (N e ; 25,000-120,000), M. m. domesticus (N e ; 58,000-200,000), and M. m. castaneus (N e ; 200,000-733,000). Mice were genotyped using a high-density single nucleotide polymorphism array, and the proportions of replacement and silent mutations within subspecies were compared with those fixed between each subspecies and an outgroup, Mus spretus. There was significant evidence of positive selection in M. m. castaneus, the lineage with the largest N e , with a estimated to be approximately 40%. In contrast, estimates of a for M. m. domesticus (a 5 13%) and for M. m. musculus (a 5 12 %) were much smaller. Interestingly, the higher estimate of a for M. m. castaneus appears to reflect not only more adaptive fixations but also more effective purifying selection. These results support the hypothesis that differences in N e contribute to differences among species in the efficacy of selection.
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Details
- Title
- Adaptive Evolution and Effective Population Size in Wild House Mice
- Creators
- Megan Phifer-Rixey - Department of Ecology and Evolutionary Biology [University of Arizona]François Bonhomme - Institut des Sciences de l'Evolution de MontpellierPierre Boursot - Institut des Sciences de l'Evolution de MontpellierGary Churchill - Jackson LaboratoryJaroslav Pialek - Czech Academy of Sciences, Institute of Vertebrate BiologyPriscilla Tucker - American Museum of Natural HistoryMichael Nachman - University of Arizona
- Publication Details
- Molecular biology and evolution, v 29(10), pp 2949-2955
- Publisher
- Oxford University Press (OUP)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology
- Web of Science ID
- WOS:000309927900009
- Scopus ID
- 2-s2.0-84866328214
- Other Identifier
- 991021229885604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Evolutionary Biology
- Genetics & Heredity