Journal article
Adaptive deep brain stimulation (aDBS) controlled by local field potential oscillations
Experimental neurology, v 245
01 Jul 2013
PMID: 23022916
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Despite their proven efficacy in treating neurological disorders, especially Parkinson's disease, deep brain stimulation COBS) systems could be further optimized to maximize treatment benefits. In particular, because current open-loop DBS strategies based on fixed stimulation settings leave the typical parkinsonian motor fluctuations and rapid symptom variations partly uncontrolled, research has for several years focused on developing novel "closed-loop" or "adaptive" DBS (aDBS) systems. aDBS consists of a simple closed-loop model designed to measure and analyze a control variable reflecting the patient's clinical condition to elaborate new stimulation settings and send them to an "intelligent" implanted stimulator. The major problem in developing an aDBS system is choosing the ideal control variable for feedback. Here we review current evidence on the advantages of neurosignal-controlled aDBS that uses local field potentials (LFPs) as a control variable, and describe the technology already available to create new aDBS systems, and the potential benefits of aDBS for patients with Parkinson's disease. (C) 2012 Published by Elsevier Inc.
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Details
- Title
- Adaptive deep brain stimulation (aDBS) controlled by local field potential oscillations
- Creators
- Alberto Priori - Ospedale MaggioreGuglielmo Foffani - Drexel UniversityLorenzo Rossi - Ospedale MaggioreSara Marceglia - Politecnico di Milano
- Publication Details
- Experimental neurology, v 245
- Publisher
- Elsevier
- Number of pages
- 10
- Grant note
- Ministero della Sanita (Italy) Neuron-48-013 / ERANET-Neuron Grant "PhysiolDBS" Universita degli Studi di Milano (Italy) Ministero dell'Universita e della Ricerca Scientifica e Tecnologica (Italy); Ministry of Education, Universities and Research (MIUR) Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milan, Italy)
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000320350300009
- Scopus ID
- 2-s2.0-84878462972
- Other Identifier
- 991019353718504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences