Journal article
Adaptive optics confocal microscopy using direct wavefront sensing
Optics letters, v 36(7), pp 1062-1064
01 Apr 2011
PMID: 21478983
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Optical aberrations due to the inhomogeneous refractive index of tissue degrade the resolution and brightness of images in deep-tissue imaging. We introduce a confocal fluorescence microscope with adaptive optics, which can correct aberrations based on direct wavefront measurements using a Shack-Hartmann wavefront sensor with a fluorescent bead used as a point source reference beacon. The results show a 4.3 x improvement in the Strehl ratio and a 240% improvement in the signal intensity for fixed mouse tissues at depths of up to 100 mu m. (C) 2011 Optical Society of America
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Details
- Title
- Adaptive optics confocal microscopy using direct wavefront sensing
- Creators
- Xiaodong Tao - University of California, Santa CruzBautista Fernandez - University of California, Santa CruzOscar Azucena - University of California, Santa CruzMin Fu - University of California, Santa CruzDenise Garcia - University of California, Santa CruzYi Zuo - University of California, Santa CruzDiana C. Chen - Lawrence Livermore Natl Lab, Livermore, CA 94550 USAJoel Kubby - University of California, Santa Cruz
- Publication Details
- Optics letters, v 36(7), pp 1062-1064
- Publisher
- Optical Soc Amer
- Number of pages
- 3
- Grant note
- 0852742 / National Science Foundation (NSF)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biology; College of Arts and Sciences; Drexel University
- Web of Science ID
- WOS:000289251000012
- Scopus ID
- 2-s2.0-79956140205
- Other Identifier
- 991020111220204721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Optics