Journal article
Additive Effects of Thermal Injury and Infection on Gut Permeability
Archives of surgery (Chicago. 1960), v 129(3), pp 325-328
01 Mar 1994
PMID: 8129610
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
OBJECTIVE: To determine the effects of burn size and burn wound infection on gut permeability to the macromolecule polyethylene glycol 3350 (PEG 3350; molecular weight, 3350 d). DESIGN: Randomized, controlled study using 36 male Sprague-Dawley rats. SETTING: Hospital research laboratory. INTERVENTIONS: Animals received scald burns to 0%, 20%, or 35% of their total body surface area. Half of the animals in each group were infected with Pseudomonas aeruginosa. MAIN OUTCOME MEASURES: Gut permeability was measured using the intestinal absorption and renal excretion of enterally administered PEG 3350 and mannitol (molecular weight, 182 d). RESULTS: There were dramatic increases in PEG 3350 excretion and in the PEG 3350/mannitol ratios (P=.0001 in both instances) that were seen in relation to burn size. Significant increases in PEG 3350 excretion and in the PEG 3350/mannitol ratios (P=.017 and P=.045, respectively) were also seen in animals in which infection was present. This was in addition to the effects of burn size already noted. CONCLUSIONS: A direct relationship between gut permeability and the extent of burn injury was found, which is consistent with the results from a previous study in humans. In addition, this study found that further separate increases in gut permeability occur in the presence of P aeruginosa in burn wound infections.(Arch Surg. 1994;129:325-328)
Metrics
Details
- Title
- Additive Effects of Thermal Injury and Infection on Gut Permeability
- Creators
- Colleen M Ryan - Massachusetts General HospitalStephen H BaileyEdward A CarterDavid A SchoenfeldRonald G Tompkins
- Publication Details
- Archives of surgery (Chicago. 1960), v 129(3), pp 325-328
- Publisher
- American Medical Association
- Number of pages
- 4
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Cardiothoracic Surgery
- Web of Science ID
- WOS:A1994NA52000017
- Scopus ID
- 2-s2.0-0028257953
- Other Identifier
- 991021960814604721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Surgery