Journal article
Additive Wake-Promoting Actions of Medial Basal Forebrain Noradrenergic alpha 1- and beta -Receptor Stimulation
Behavioral neuroscience, v 117(2), pp 350-359
01 Apr 2003
PMID: 12708531
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The locus coeruleus-noradrenergic system exerts an activating influence on forebrain neuronal and behavioral activity states, in part through the actions of noradrenergic beta -receptors in the medial septal (MS) and medial preoptic (MPOA) areas. MPOA alpha 1-receptors exert similar wake-promoting actions. The current study examines the influence of alpha 1-receptors located within MS on sleep-wake state. In addition, the extent to which alpha 1- and beta -receptors located within MS and MPOA interact in the modulation of behavioral state was investigated by examining the effects of individual or combined infusion of alpha 1- and beta -agonists into these regions. Results show that alpha 1-receptors located within MS exert wake-promoting actions. Within both MS and MPOA, additive wake-promoting actions were observed with alpha 1- and beta -receptor stimulation, the sum of which contributes to the overall arousal state of the animal.
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Details
- Title
- Additive Wake-Promoting Actions of Medial Basal Forebrain Noradrenergic alpha 1- and beta -Receptor Stimulation
- Creators
- C W BerridgeS O IsaacR A Espana
- Publication Details
- Behavioral neuroscience, v 117(2), pp 350-359
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000181880600017
- Scopus ID
- 2-s2.0-0037380661
- Other Identifier
- 991014877775104721
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- Web of Science research areas
- Behavioral Sciences
- Neurosciences