Journal article
Addressing the need for standardization of symptomatic medication documentation in Parkinson's disease clinical research: A call to action
Journal of Parkinson's disease, v 15(1), pp 227-235
01 Feb 2025
PMID: 39973486
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
People with Parkinson's disease (PD) are prescribed a variety of medications to mitigate symptoms and improve their quality of life. These symptomatic therapies cover a range of pharmacological classes, including classical dopaminergic treatments, other antiparkinsonian agents, and pharmacotherapies for non-PD conditions. Often, medications are prescribed for concomitant use and in increasing doses, particularly as the disease progresses. Documentation of these interventions in clinical trials is necessary to accurately capture medication usage, compare medication utilization across different studies, understand factors contributing to experimental therapeutic response, and analyze clinical trial data in a precise manner. At the present time, there is no current international standard for how these medications are documented within clinical trials. As a case example, we will highlight medication use documentation in a large international multicenter observational study commonly used as a reference for design of clinical trials. This review aims to raise awareness within the scientific community of the importance of proper medication documentation and the need for standardization to harmonize prescriptive practices, improve treatment interpretability, and perform consistently robust analyses from clinical trials data.
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Details
- Title
- Addressing the need for standardization of symptomatic medication documentation in Parkinson's disease clinical research: A call to action
- Creators
- Mikayla Spott - Critical Path InstituteMonica Javidnia - University of RochesterAnne Pedata - Critical Path InstituteMartijn Müller - Critical Path InstituteLaura Carrillo - Critical Path InstituteTanya Simuni - Northwestern UniversityGennaro Pagano - Roche (Switzerland)Kevin Kwok - Parkinson's FoundationKlaus Romero - Critical Path InstituteDiane Stephenson - Critical Path Institute
- Publication Details
- Journal of Parkinson's disease, v 15(1), pp 227-235
- Publisher
- SAGE Publications
- Grant note
- U18 FD005320 / FDA HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:001482265000001
- Scopus ID
- 2-s2.0-105002427291
- Other Identifier
- 991022197431504721
UN Sustainable Development Goals (SDGs)
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences