Journal article
Adenocarcinoma of the Esophagus in the Young
Journal of gastrointestinal surgery, v 17(6), pp 1032-1035
01 Jun 2013
PMID: 23564309
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Practitioners have noted a striking increase in the number of young patients under the age of 40 years old who develop esophageal adenocarcinoma. The aim of this study was to characterize the presentation, pathology and therapeutic outcome of these young patients.
The records of patients who presented to the Foregut Surgical Service at the University of Southern California with esophageal adenocarcinoma between 2000 and 2007 were retrospectively reviewed. The presentation, tumor stage and histology, therapy and outcome of the patients under the age of 40 were compared to those a parts per thousand yen40.
Of the 374 patients reviewed, 20 (5 %) were under the age of 40. There were two patients in their second and 18 in their third decade of life. The youngest patient was 25 years old. A history of gastroesophageal reflux disease or Barrett's esophagus was less common in patients < 40 than in those a parts per thousand yen40; 15 and 5 % compared to 61 and 46 %. Similarly, patients < 40 had a significantly longer time interval between the onset of symptoms and the diagnosis of their cancer than those a parts per thousand yen40; 4.5 vs. 2 months, p = 0.04. They also had a higher prevalence of stage IV disease (30 vs. 6 %, p = 0.0003), a shorter time to recurrence (9.5 vs.19 month, p = 0.002), and a poorer median survival (17 vs. 43 month, p = 0.04).
Esophageal adenocarcinoma in patients < 40 years old commonly presents with an advanced stage of the disease and an associated poor survival. This is likely due to a low index of suspicion that dysphagia seen in younger patients is due to a malignancy.
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Details
- Title
- Adenocarcinoma of the Esophagus in the Young
- Creators
- Arzu Oezcelik - University of Southern CaliforniaShahin Ayazi - University of Southern CaliforniaSteven R. DeMeester - University of Southern CaliforniaJoerg Zehetner - University of Southern CaliforniaEmmanuele Abate - University of Southern CaliforniaJoie Dunn - University of Southern CaliforniaKimberly S. Grant - University of Southern CaliforniaJohn C. Lipham - University of Southern CaliforniaJeffrey A. Hagen - University of Southern CaliforniaTom R. DeMeester - University of Southern California
- Publication Details
- Journal of gastrointestinal surgery, v 17(6), pp 1032-1035
- Publisher
- Springer Nature
- Number of pages
- 4
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Surgery
- Web of Science ID
- WOS:000318901800002
- Scopus ID
- 2-s2.0-84877765880
- Other Identifier
- 991022048290904721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Gastroenterology & Hepatology
- Surgery