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Adenosine 5'-triphosphate axis in obstructive airway diseases
Journal article   Peer reviewed

Adenosine 5'-triphosphate axis in obstructive airway diseases

Amir Pelleg and Edward S Schulman
American journal of therapeutics, v 9(5), pp 454-464
Sep 2002
DOI: https://doi.org/10.1097/00045391-200209000-00014
PMID: 12237739

Abstract

Adenosine Triphosphate - physiology Adenosine Triphosphate - therapeutic use Asthma - drug therapy Asthma - physiopathology Clinical Trials as Topic Humans Pulmonary Disease, Chronic Obstructive - drug therapy Pulmonary Disease, Chronic Obstructive - physiopathology Receptors, Purinergic - drug effects Signal Transduction - drug effects
In recent years, significant progress has been made in our understanding of the pathophysiology behind obstructive airway diseases in general and asthma in particular; this knowledge, however, has not translated to major breakthroughs in the treatment of these disorders. Current therapeutic options are less than optimal and frequently are associated with systemic adverse effects. Recent studies indicate that endogenous purine nucleotides, adenosine 5'-triphosphate (ATP) in particular, could play a mechanistic role in obstructive airway diseases through their actions on multiple cell types relevant to these disorders, including mast cells, eosinophils, dendritic cells, and neurons. The pharmacologic modulation of ATP signal transduction in these cells represents an attractive new therapeutic target.

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