Journal article
Adenosine 5'-triphosphate axis in obstructive airway diseases
American journal of therapeutics, v 9(5), pp 454-464
Sep 2002
PMID: 12237739
Abstract
In recent years, significant progress has been made in our understanding of the pathophysiology behind obstructive airway diseases in general and asthma in particular; this knowledge, however, has not translated to major breakthroughs in the treatment of these disorders. Current therapeutic options are less than optimal and frequently are associated with systemic adverse effects. Recent studies indicate that endogenous purine nucleotides, adenosine 5'-triphosphate (ATP) in particular, could play a mechanistic role in obstructive airway diseases through their actions on multiple cell types relevant to these disorders, including mast cells, eosinophils, dendritic cells, and neurons. The pharmacologic modulation of ATP signal transduction in these cells represents an attractive new therapeutic target.
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Details
- Title
- Adenosine 5'-triphosphate axis in obstructive airway diseases
- Creators
- Amir Pelleg - Hahnemann University HospitalEdward S Schulman
- Publication Details
- American journal of therapeutics, v 9(5), pp 454-464
- Publisher
- Lippincott
- Grant note
- R01- 40036 / PHS HHS AI-20634 / NIAID NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pulmonary, Critical Care, and Sleep (Medicine)
- Scopus ID
- 2-s2.0-0036730092
- Other Identifier
- 991019295304504721