Journal article
Adenosine 5'-triphosphate's role in bradycardia and syncope associated with pulmonary embolism
Respiratory research, v 19(1), pp 142-142
28 Jul 2018
PMID: 30055609
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Adenosine 5'-triphiosphate (ATP) is released from cells under physiologic and pathophysiologic conditions. Extracellular ATP acts as an autocrine and paracrine agent affecting various cell types by activating cell surface P2 receptors (P2R), which include trans-cell membrane cationic channels, P2XR, and G protein coupled receptors, P2YR. We have previously shown that ATP stimulates vagal afferent nerve terminals in the lungs by activating P2X2/3R. This action could lead to bronchoconstriction, cough and the local release of pro-inflammatory neuropeptides. In addition, ATP markedly enhances the IgE-dependent histamine release from human lung mast cells. Thus, we have proposed for the first time that extracellular ATP plays a mechanistic role in pulmonary pathophysiology in general and chronic obstructive pulmonary disease (COPD), and acute bronchoconstriction in asthma in particular. The present review examines whether ATP could also play a role in bradycardia and syncope in a subset of patients with pulmonary embolism.
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Details
- Title
- Adenosine 5'-triphosphate's role in bradycardia and syncope associated with pulmonary embolism
- Creators
- Amir Pelleg - Department of Medicine, Drexel University, College of Medicine, NCB, MS# 470, 245 N 15th Street, Philadelphia, PA, 19102, USA. ap33@drexel.eduEdward S Schulman - Department of Medicine, Drexel University, College of Medicine, NCB, MS# 470, 245 N 15th Street, Philadelphia, PA, 19102, USAPeter J Barnes - Airway Disease Section, National Heart and Lung Institute, Imperial College, London, UK
- Publication Details
- Respiratory research, v 19(1), pp 142-142
- Publisher
- Springer BMC; England
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pulmonary, Critical Care, and Sleep (Medicine)
- Web of Science ID
- WOS:000440219900002
- Scopus ID
- 2-s2.0-85050701900
- Other Identifier
- 991014877806504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Respiratory System