Journal article
Adenosine in the mammalian heart: nothing to get excited about
Trends in pharmacological sciences (Regular ed.), v 18(4), pp 236-238
1997
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Abstract
Until quite recently, the cardiodepressant actions of adenosine were widely accepted. A nucleoside that produces negative chronotropic and ionotropic effects, adenosine, has been used clinically as the drug of choice for terminating supraventricular (atrioventricular node) tachycardia and is likely to play an important part in regulating arrhythmogenic activity as an endogenous antiarrhythmic metabolite. Despite this, recent experimental data, particularly resulting from
in vitro studies using animal models, have shown a paradoxical excitable action of adenosine in the heart. In this article,
Amir Pelleg and Steven Kutalek present the reasons why they continue to believe that any excitatory actions of adenosine in the heart are clinically irrelevant.
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Details
- Title
- Adenosine in the mammalian heart: nothing to get excited about
- Creators
- Amir Pelleg - Professor, Allegheny University of Health Sciences, Likoff Cardiovascular Institute, Department of Medicine, Philadelphia, PA 19102-1192, USASteven P. Kutalek - Allegheny University of Health Sciences, Likoff Cardiovascular Institute, Department of Medicine, Philadelphia, PA 19102-1192, USA
- Publication Details
- Trends in pharmacological sciences (Regular ed.), v 18(4), pp 236-238
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine
- Web of Science ID
- WOS:A1997XM26700005
- Other Identifier
- 991019340588804721
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- Web of Science research areas
- Pharmacology & Pharmacy