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Adherence of Candida albicans to Human Vaginal and Buccal Epithelial Cells
Journal article   Peer reviewed

Adherence of Candida albicans to Human Vaginal and Buccal Epithelial Cells

J. D. Sobel, P. G. Myers, D. Kaye and M. E. Levison
The Journal of infectious diseases, v 143(1), pp 76-82
Jan 1981
DOI: https://doi.org/10.1093/infdis/143.1.76
PMID: 7012245
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Factors that may influence adherence of Candida albicans to exfoliated human vaginal and buccal epithelial cells were studied in vitro. Factors that enhanced germination enhanced adherence. Heat-killed, germinated Candida organisms demonstrated poorer adherence than viable Candida organisms and no better adherence than nonviable, ungerminated Candida organisms. The difference between adherence of C. albicans to buccal epithelial cells and that to vaginal epithelial cells was significant, as were differences among volunteers. Preincubation in fucose but not mannose, glucose, or galactose solutions, preincubation of germinated yeast or of epithelial cells in chymotrypsin or trypsin, a culture supernatant of germinated yeast killed by ultraviolet light, or precoating of epithelial cells with lactobacilli each inhibited adherence. These studies indicate that adherence of C. albicans is enhanced by a surface component of germinated yeast, probably a surface protein that binds to the epithelial receptor, possibly a glycoprotein.

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204 citations in Web of Science
168 citations in Scopus

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Collaboration types
Domestic collaboration
Web of Science research areas
Immunology
Infectious Diseases
Microbiology
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