Journal article
Adherence to statin therapy favours survival of patients with symptomatic peripheral artery disease
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY, v 7(4)
Jul 2021
PMID: 31886861
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Aims We hypothesized that adherence to statin therapy determines survival in patients with peripheral artery disease (PAD). Methods and results Single-centre longitudinal observational study with 691 symptomatic PAD patients. Mortality was evaluated over a mean follow-up of 50 +/- 26 months. We related statin adherence and low-density lipoprotein cholesterol (LDL-C) target attainment to all-cause mortality. Initially, 73% of our PAD patients were on statins. At follow-up, we observed an increase to 81% (P<0.0001). Statin dosage, normalized to simvastatin 40 mg, increased from 50 to 58 mg/day (P<0.0001), and was paralleled by a mean decrease of LDL-C from 97 to 82 mg/dL (P<0.0001). The proportion of patients receiving a high-intensity statin increased over time from 38% to 62% (P<0.0001). Patients never receiving statins had a significant higher mortality rate (31%) than patients continuously on statins (13%) or having newly received a statin (8%; P<0.0001). Moreover, patients on intensified statin medication had a low mortality of 9%. Those who terminated statin medication or reduced statin dosage had a higher mortality (34% and 20%, respectively; P<0.0001). Multivariate analysis showed that adherence to or an increase of the statin dosage (both P=0.001), as well as a newly prescribed statin therapy (P=0.004) independently predicted reduced mortality. Conclusion Our data suggest that adherence to statin therapy is associated with reduced mortality in symptomatic PAD patients. A strategy of intensive and sustained statin therapy is recommended.
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Details
- Title
- Adherence to statin therapy favours survival of patients with symptomatic peripheral artery disease
- Publication Details
- EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY, v 7(4)
- Publisher
- OXFORD UNIV PRESS; OXFORD
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:000684090200009
- Scopus ID
- 2-s2.0-85112193879
- Other Identifier
- 991021860660804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems
- Pharmacology & Pharmacy