Journal article
Adhesion induced by mobile cross-bridges: Steady state peeling of conjugated cell pairs
Journal of theoretical biology, v 140(1), pp 1-17
11 Sep 1989
PMID: 2615387
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Recent experiments on cell-cell adhesion indicate that (i) bonds between two cells migrate towards the region of conjugation during peeling, and (ii) cell membrane tension increases with the rate of peeling. Analytical methods that would allow the derivation of intrinsic parameters of adhesion from such experimental data have yet to be explored. In this study we introduce a specific adhesion model to investigate the complex interaction between rate of peeling, lateral diffusivity and the rate of detachment of bonds. Our analysis show that adhesive energy density increases with the rate of peeling and with lateral diffusivity of the bonds but decreases with increasing rate of detachment. The rate dependency of the adhesive energy is due to the modulation of the number density distribution of bonds by the speed of peeling.
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Details
- Title
- Adhesion induced by mobile cross-bridges: Steady state peeling of conjugated cell pairs
- Creators
- Aydin Tozeren - Catholic University of America
- Publication Details
- Journal of theoretical biology, v 140(1), pp 1-17
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; [Retired Faculty]
- Web of Science ID
- WOS:A1989AQ71600001
- Scopus ID
- 2-s2.0-0024440311
- Other Identifier
- 991021895794104721
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- Web of Science research areas
- Biology
- Mathematical & Computational Biology