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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Adipocytokines, Inflammation, and Breast Cancer Risk in Postmenopausal Women: A Prospective Study
Cancer epidemiology, biomarkers & prevention, v 22(7), pp 1319-1324
01 Jul 2013
PMID: 23651666
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Obesity is a known risk factor for postmenopausal breast cancer; it has been postulated that adipocytokines may mediate this association. We explored the relationship between three markers altered by obesity: leptin, adiponectin, and soluble tumor necrosis factor receptor 2 (sTNF-R2), an inflammatory marker, with breast cancer risk in postmenopausal women. A nested case-control study of postmenopausal women was conducted within CLUE II, a prospective population-based cohort. Baseline plasma levels of leptin, adiponectin, and sTNF-R2 were assayed in 272 female breast cancer cases and 272 controls matched on age, date, and hour of blood draw. Conditional logistic regression was used to estimate matched odds ratios (OR) and 95% confidence intervals (CI). sTNF-R2 and leptin were independently positively associated with breast cancer risk in adjusted models. The OR for breast cancer comparing the highest to lowest tertile was 2.44 (95% CI: 1.30-4.58) for sTNF-R2 and 1.98 (95% CI: 1.20-3.29) for leptin. While higher levels of adiponectin were protective (OR for the lowest tertile = 1.63; 95% CI: 1.02-2.60), there was no dose response. A 20% reduction in the breast cancer risk associated with overweight/obesity was observed when sTNF-R2 alone was included in multivariable models. Including both sTNF-R2 and adiponectin in the models resulted in a 29% reduction in the OR. Adipocytokines and sTNF-R2 are important factors in the etiology of postmenopausal breast cancer due to adiposity. This study informs our understanding of the relationship between obesity, inflammation, and postmenopausal breast cancer and identifies potential biomarkers. 24. (C) 2013 AACR.
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Details
- Title
- Adipocytokines, Inflammation, and Breast Cancer Risk in Postmenopausal Women: A Prospective Study
- Creators
- Amy L. Gross - BloombergCraig J. Newschaffer - Health & Life (Taiwan)Judith Hoffman-Bolton - Center for Clinical Research and PreventionNader Rifai - Harvard University ,Kala Visvanathan - Bloomberg
- Publication Details
- Cancer epidemiology, biomarkers & prevention, v 22(7), pp 1319-1324
- Publisher
- Amer Assoc Cancer Research
- Number of pages
- 6
- Grant note
- DAMD-17-01-1-0284; DAMD17-01-1-0537 / DOD; United States Department of Defense T32 CA009314 / NCI; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) Breast Cancer Research Foundation T32CA009314 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000321323600015
- Scopus ID
- 2-s2.0-84880011766
- Other Identifier
- 991019168654904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Oncology
- Public, Environmental & Occupational Health