Journal article
Adiponectin and the mediation of HDL-cholesterol change with improved lifestyle: the Look AHEAD Study[S]
Journal of lipid research, v 53(12), pp 2726-2733
Dec 2012
PMID: 22956782
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Adipose tissue dysfunction plays a key role in the development of the metabolic abnormalities characteristic of type 2 diabetes (T2DM) and participates actively in lipid metabolism. Adiponectin, found abundantly in circulation and a marker of adipose health, is decreased in obese persons with T2DM. We investigated whether the changes in adiponectin with an intensive lifestyle intervention (ILI) for weight loss could potentially mediate the increase in low HDL-cholesterol (HDL-C) with ILI. Adiponectin and its fractions were determined using an ELISA with selective protease treatment in 1,397 participants from Look AHEAD, a trial examining whether ILI will reduce cardiovascular events in overweight/obese subjects with T2DM when compared with a control arm, diabetes support and education (DSE). Multivariable regression and mediational analyses were performed for adiponectin and its high-molecular-weight (HMW) and non-HMW fractions. ILI increased baseline HDL-C by 9.7% and adiponectin by 11.9%; changes with DSE were 1.3% and 0.2%, respectively (P < 0.0001). In a model including changes in weight, fitness, triglycerides, and glucose control and that adjusted for demographics and medical history, adiponectin changes remained significantly associated with HDL-C change. Data supported the contribution of changes in both HMW- and non-HMW-adiponectin to the improvement in HDL-C with ILI
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Details
- Title
- Adiponectin and the mediation of HDL-cholesterol change with improved lifestyle: the Look AHEAD Study[S]
- Creators
- L. Maria Belalcazar - The University of Texas Medical Branch at GalvestonWei Lang - Wake Forest UniversitySteven M. Haffner - The University of Texas Health Science Center at San AntonioRon C. Hoogeveen - Baylor College of MedicineF. Xavier Pi-Sunyer - St. Luke's-Roosevelt Hospital CenterDawn C. Schwenke - Arizona State UniversityAshok Balasubramanyam - University of VermontRussell P. Tracy - University of VermontAndrea P. Kriska - University of PittsburghChristie M. Ballantyne - Baylor College of MedicineLook AHEAD Res GrpEllen Stephanie Krauthamer Ewing - Drexel University
- Publication Details
- Journal of lipid research, v 53(12), pp 2726-2733
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Counseling and Family Therapy; Drexel University
- Web of Science ID
- WOS:000310905000021
- Scopus ID
- 2-s2.0-84869024719
- Other Identifier
- 991020100210104721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology