Journal article
Adiposity, body composition, and weight change in relation to organochlorine pollutant plasma concentrations
Journal of exposure science & environmental epidemiology, v 22(6), pp 617-624
01 Nov 2012
PMID: 22588213
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We investigated cross-sectional associations of body composition and weight change with polychlorinated biphenyls (PCB) and organochlorine pesticides/pesticide metabolites measured in blood collected at the baseline of the Physical Activity for Total Health study of postmenopausal, overweight women living in the Seattle, Washington metropolitan area. Indicators of greater adiposity were associated with lower plasma concentrations of most PCBs with six or more chlorine atoms. This pattern was observed for current weight, body mass index, fat mass percent, subcutaneous abdominal fat, intra-abdominal fat, waist circumference, hip circumference, waist-to-hip ratio, and maximum adult weight. Conversely, PCB 105, PCB 118, and p,p'-DDE were generally increased or showed no association with these variables. Weight gain since age 35 was associated with lower concentrations of almost every organochlorine we studied, and past weight loss episodes of at least 20 pounds (>= 9.1 kg) were associated with higher concentrations. Our results have implications for epidemiologic studies of organochlorines in terms of covariates that may be important to consider in statistical analyses, particularly as such considerations may differ importantly by specific analyte. Our finding of increased organochlorine concentrations with past weight loss episodes may have public health significance; however, this association requires confirmation in longitudinal studies.
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Details
- Title
- Adiposity, body composition, and weight change in relation to organochlorine pollutant plasma concentrations
- Creators
- Anneclaire J. De Roos - Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South AfricaCornelia M. Ulrich - Hutchinson (Canada)Andreas Sjodin - Centers for Disease Control and PreventionAnne McTiernan - Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa
- Publication Details
- Journal of exposure science & environmental epidemiology, v 22(6), pp 617-624
- Publisher
- Springer Nature
- Number of pages
- 8
- Grant note
- R03ES015787 / National Institute of Environmental Health Sciences of the National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS) R03ES015787 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:000309989900010
- Scopus ID
- 2-s2.0-84867901188
- Other Identifier
- 991020099618604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Environmental Sciences
- Public, Environmental & Occupational Health
- Toxicology