Journal article
Adjunctive Therapy to Manage Neuropsychiatric Symptoms in Moderate and Severe Dementia: Randomized Clinical Trial Using an Outpatient Version of Tailored Activity Program
Journal of Alzheimer's disease, v 83(1), pp 475-486
2021
PMID: 34334394
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Neuropsychiatric symptoms (NPS) such as aggression, apathy, agitation, and wandering may occur in up to 90%of dementia cases. International guidelines have suggested that non-pharmacological interventions are as effective as pharmacological treatments, however without the side effects and risks of medications. An occupational therapy method, called Tailored Activity Program (TAP), was developed with the objective to treat NPS in the elderly with dementia and has been shown to be effective.
Evaluate the efficacy of the TAP method (outpatient version) in the treatment of NPS in individuals with dementia and in the burden reduction of their caregivers.
This is a randomized, double-blind, controlled clinical trial for the treatment of NPS in dementia. Outcome measures consisted of assessing the NPS of individuals with dementia, through the Neuropsychiatric Inventory-Clinician rating scale (NPI-C), and assessing the burden on their caregivers, using the Zarit Scale. All the participants were evaluated pre-and post-intervention.
54 individuals with dementia and caregivers were allocated to the experimental (n = 28) and control (n = 26) groups. There was improvement of the following NPS in the experimental group: delusions, agitation, aggressiveness, depression, anxiety, euphoria, apathy, disinhibition, irritability, motor disturbance, and aberrant vocalization. No improvement was observed in hallucinations, sleep disturbances, and appetite disorders. The TAP method for outpatient settings was also clinically effective in reducing burden between caregivers of the experimental group.
The use of personalized prescribed activities, coupled with the caregiver training, may be a clinically effective approach to reduce NPS and caregiver burden of individuals with dementia.
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Details
- Title
- Adjunctive Therapy to Manage Neuropsychiatric Symptoms in Moderate and Severe Dementia: Randomized Clinical Trial Using an Outpatient Version of Tailored Activity Program
- Creators
- Alexandra Martini Oliveira - Laboratorio de Neurociencias (LIM-27), Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo, BrazilMarcia Radanovic - Hospital das Clínicas da Faculdade de Medicina da Universidade de São PauloPatricia Cotting Homem de Mello - Serviço de Terapia Ocupacional, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo, BrazilPatricia Cardoso Buchain - Hospital das Clínicas da Faculdade de Medicina da Universidade de São PauloAdriana Dias Barbosa Vizzotto - Hospital das Clínicas da Faculdade de Medicina da Universidade de São PauloJanaína Harder - Hospital das Clínicas da Faculdade de Medicina da Universidade de São PauloFlorindo Stella - Hospital das Clínicas da Faculdade de Medicina da Universidade de São PauloLaura N Gitlin - Johns Hopkins UniversityCatherine Verrier Piersol - Thomas Jefferson UniversityLeandro L C Valiengo - Hospital das Clínicas da Faculdade de Medicina da Universidade de São PauloOrestes Vicente Forlenza - Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
- Publication Details
- Journal of Alzheimer's disease, v 83(1), pp 475-486
- Publisher
- IOS Press
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Nursing and Health Professions
- Web of Science ID
- WOS:000692658700037
- Scopus ID
- 2-s2.0-85114398258
- Other Identifier
- 991019169652504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences