Journal article
Adolescent epigenetic profiles and environmental exposures from early life through peri-adolescence
Environmental epigenetics, v 2(3), pp dvw018-dvw018
14 Aug 2016
PMID: 29492298
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Epigenetic perturbations induced by environmental exposures at susceptible lifestages contribute to disease development. Even so, the influence of early life and ongoing exposures on the adolescent epigenome is rarely examined. We examined the association of exposure biomarkers for lead (Pb), bisphenol A (BPA), and nine phthalates metabolites with blood leukocyte DNA methylation at LINE-1 repetitive elements and environmentally responsive genes (
IGF2
,
H19
, and
HSD11B2
) in peri-adolescents. Participants (
n
= 247) from the Early Life Exposures in Mexico to Environmental Toxicants (ELEMENT) birth cohorts were followed-up once between the ages of 8 and 14 years, and concurrent exposures were measured in biospecimen collected at that time (blood Pb, urinary BPA, and phthalate metabolites). Prenatal and childhood exposures to Pb were previously approximated using maternal and child samples. BPA and phthalate metabolites were measured in third trimester maternal urine samples. Significant associations (
P
< 0.05) were observed between DNA methylation and exposure biomarkers that were gene and biomarker specific. For example, Pb was only associated with LINE-1 hypomethylation during pregnancy (
P
= 0.04), while early childhood Pb was instead associated with
H19
hypermethylation (
P
= 0.04). Concurrent urinary mono (2-ethylhexyl) phthalate (MEHP) was associated with
HSD11B2
hypermethylation (
P
= 0.005). Sex-specific associations, particularly among males, were also observed. In addition to single exposure models, principal component analysis was employed to examine exposure mixtures. This method largely corroborated the findings of the single exposure models. This study along with others in the field suggests that environment-epigenetic relationships vary by chemical, exposure timing, and sex.
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Details
- Title
- Adolescent epigenetic profiles and environmental exposures from early life through peri-adolescence
- Creators
- Jaclyn M. Goodrich - University of MichiganDana C. Dolinoy - University of MichiganBrisa N. Sánchez - University of MichiganZhenzhen Zhang - University of MichiganJohn D. Meeker - University of MichiganAdriana Mercado-Garcia - University of MichiganMaritsa Solano-González - University of MichiganHoward Hu - University of TorontoMartha M. Téllez-Rojo - University of MichiganKaren E. Peterson - University of Michigan
- Publication Details
- Environmental epigenetics, v 2(3), pp dvw018-dvw018
- Publisher
- Oxford University Press
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000456022900006
- Scopus ID
- 2-s2.0-85048229162
- Other Identifier
- 991020099178404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Genetics & Heredity
- Toxicology