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Adolescent risk-taking as a function of prenatal cocaine exposure and biological sex
Journal article   Open access   Peer reviewed

Adolescent risk-taking as a function of prenatal cocaine exposure and biological sex

Jedediah W.P. Allen, David S. Bennett, Dennis P. Carmody, Yiping Wang and Michael Lewis
Neurotoxicology and teratology, v 41
Jan 2014
DOI: https://doi.org/10.1016/j.ntt.2013.12.003
PMID: 24334262
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1016/j.ntt.2013.12.003View
Published, Version of Record (VoR)Open Access (License Unspecified),  Open

Abstract

Adolescence Biological sex Prenatal cocaine exposure Risk-taking
To examine the effects of prenatal cocaine exposure and biological sex on adolescent risk-taking while controlling for early environmental risk. Adolescents (n=114, mean age=16) were grouped according to high and low risk-taking propensity as measured by the Balloon Analogue Risk Task (BART). Prenatal cocaine exposure was assessed at birth, while environmental risk was assessed at three points during early childhood. A binary regression analysis indicated that males were 3.5 times more likely than females to be high risk-takers. Biological sex and prenatal cocaine exposure interacted such that exposed males were most likely to be high risk-takers while exposed females were the least likely to be high risk-takers. This pattern held after controlling for prenatal alcohol exposure and early environmental risk. Early environmental risk did not predict adolescent risk-taking. These findings complement and extend earlier research demonstrating that prenatal cocaine exposure interacts with biological sex in domains related to inhibitory control, emotion regulation, antisocial behavior, and health risk behaviors during preadolescence. •Males were 3.5 times more likely than females to be high risk-takers.•Prenatal cocaine exposure increased adolescent risk-taking in males but not females.•After controlling for alcohol, cocaine-exposed females showed increased risk-aversion relative to their unexposed peers.•Under certain conditions, males and females may have different response profiles to risk-taking.

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13 citations in Web of Science
19 citations in Scopus

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Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Neurosciences
Toxicology
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