Journal article
Adsorption of Drugs on Nanodiamond: Toward Development of a Drug Delivery Platform
Molecular pharmaceutics, v 10(10), pp 3728-3735
01 Oct 2013
PMID: 23941665
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Nanodiamond particles produced by detonation synthesis and having similar to 5 nm diameter possess unique properties, including low cell toxicity, biocompatibility, stable structure, and highly tailorable surface chemistry, which render them an attractive material for developing drug delivery systems. Although the potential for nanodiamonds in delivery and sustained release of anticancer drugs has been recently demonstrated, very little is known about the details of adsorption/desorption equilibria of these and other drugs on/from nanodiamonds with different purity, surface chemistry, and agglomeration state. Since adsorption is the basic mechanism most commonly used for the loading of drugs onto nanodiamond, the fundamental studies into the details of adsorption and desorption on nanodiamond are critically important for the rational design of the nanodiamond drug delivery systems capable of targeted delivery and triggered release, while minimizing potential leaks of dangerous drugs. In this paper we report on a physical-chemical study of the adsorption of doxorubicin and polyrprin B on nanodiamonds, analyzing the role of purification and surface chemistry of the adsorbent.
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Details
- Title
- Adsorption of Drugs on Nanodiamond: Toward Development of a Drug Delivery Platform
- Creators
- Vadym N. Mochalin - Drexel UniversityAmanda Pentecost - Drexel UniversityXue-Mei Li - Shanghai#R#Advanced#R#Research Institute, Chinese Academy of Science, 99 Haike Road, Zhang-Jiang Hi-Tech Park, Pudong, Shanghai 201210, ChinaIoannis Neitzel - Drexel UniversityMatthew Nelson - Drexel UniversityChongyang Wei - Shanghai#R#Advanced#R#Research Institute, Chinese Academy of Science, 99 Haike Road, Zhang-Jiang Hi-Tech Park, Pudong, Shanghai 201210, ChinaTao He - Chinese Acad Sci, Shanghai Adv Res Inst, Shanghai 201210, Peoples R ChinaFang Guo - Shanghai#R#Advanced#R#Research Institute, Chinese Academy of Science, 99 Haike Road, Zhang-Jiang Hi-Tech Park, Pudong, Shanghai 201210, ChinaYury Gogotsi - Drexel University
- Publication Details
- Molecular pharmaceutics, v 10(10), pp 3728-3735
- Publisher
- American Chemical Society; Washington, DC
- Number of pages
- 8
- Grant note
- Drexel-SARI (Shanghai Advanced Research Institute, Chinese Academy of Sciences) Center
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Materials Science and Engineering
- Web of Science ID
- WOS:000326319900019
- Scopus ID
- 2-s2.0-84888384768
- Other Identifier
- 991019167640504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Medicine, Research & Experimental
- Pharmacology & Pharmacy