Journal article
Adult Human Glioblastomas Harbor Radial Glia-like Cells
STEM CELL REPORTS, v 14(2), pp 338-350
11 Feb 2020
PMID: 32004492
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Radial glia (RG) cells are the first neural stem cells to appear during embryonic development. Adult human glioblastomas harbor a subpopulation of RG-like cells with typical RG morphology and markers. The cells exhibit the classic and unique mitotic behavior of normal RG in a cell-autonomous manner. Single-cell RNA sequencing analyses of glioblastoma cells reveal transcriptionally dynamic clusters of RG-like cells that share the profiles of normal human fetal radial glia and that reside in quiescent and cycling states. Functional assays show a role for interleukin in triggering exit from dormancy into active cycling, suggesting a role for inflammation in tumor progression. These data are consistent with the possibility of persistence of RG into adulthood and their involvement in tumor initiation or maintenance. They also provide a putative cellular basis for the persistence of normal developmental programs in adult tumors.
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Details
- Title
- Adult Human Glioblastomas Harbor Radial Glia-like Cells
- Publication Details
- STEM CELL REPORTS, v 14(2), pp 338-350
- Publisher
- CELL PRESS; CAMBRIDGE
- Number of pages
- 0
- Grant note
- The work was supported by the W.M. Keck Foundation and NIH RO1 CA208405 (to V.T.) and program grant P30 CA 008748. X.S.: Scientific Research Fund of Hunan Provincial Education Department (16B237), Chinese Scholarship Council and Chan Zuckerberg Initiative DAF (183501). X.S. and M.H.: core grant to the Wellcome Sanger Institute from the Wellcome Trust (206194). K.F.: New York Stem Cell Foundation. We thank Huatai Xu for constructive discussion and critical reading, Mark Tomishima and Kiran Ramnarine; Katia Manova, Vitaly Boyko, Fujisawa Sho, Elvin Feng, Nin Fang and Mesruh Turkekul at the Molecular Cytology Core Facility; Paul Byrne, Mark Kweens, Fang Fang, Petrina Georgala, and Rui Gardner at the Flow Cytometry Core Facility at Memorial Sloan Kettering Cancer Center, and Yara Maria Studer for graphics.
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Drexel University
- Web of Science ID
- WOS:000513921400016
- Scopus ID
- 2-s2.0-85078775920
- Other Identifier
- 991021860684204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cell & Tissue Engineering
- Cell Biology