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Journal article
Advanced Parental Age and the Risk of Autism Spectrum Disorder
American journal of epidemiology, v 168(11), pp 1268-1276
01 Dec 2008
PMID: 18945690
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This study evaluated independent effects of maternal and paternal age on risk of autism spectrum disorder. A case-cohort design was implemented using data from 10 US study sites participating in the Centers for Disease Control and Prevention's Autism and Developmental Disabilities Monitoring Network. The 1994 birth cohort included 253,347 study-site births with complete parental age information. Cases included 1,251 children aged 8 years with complete parental age information from the same birth cohort and identified as having an autism spectrum disorder based on Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision criteria. After adjustment for the other parent's age, birth order, maternal education, and other covariates, both maternal and paternal age were independently associated with autism (adjusted odds ratio for maternal age >= 35 vs. 25-29 years = 1.3, 95% confidence interval: 1.1, 1.6; adjusted odds ratio for paternal age >= 40 years vs. 25-29 years = 1.4, 95% confidence interval: 1.1, 1.8). Firstborn offspring of 2 older parents were 3 times more likely to develop autism than were third- or later-born offspring of mothers aged 20-34 years and fathers aged < 40 years (odds ratio = 3.1, 95% confidence interval: 2.0, 4.7). The increase in autism risk with both maternal and paternal age has potential implications for public health planning and investigations of autism etiology.
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Details
- Title
- Advanced Parental Age and the Risk of Autism Spectrum Disorder
- Creators
- Maureen S. Durkin - University of Wisconsin–MadisonMatthew J. Maenner - University of Wisconsin–MadisonCraig J. Newschaffer - Drexel UniversityLi-Ching Lee - Johns Hopkins UniversityChristopher M. Cunniff - University of ArizonaJulie L. Daniels - University of North Carolina at Chapel HillRussell S. Kirby - University of Alabama at BirminghamLewis Leavitt - University of Wisconsin–MadisonLisa Miller - University of WisconsinWalter Zahorodny - Rutgers, The State University of New JerseyLaura A. Schieve - Centers for Disease Control and Prevention
- Publication Details
- American journal of epidemiology, v 168(11), pp 1268-1276
- Publisher
- Oxford Univ Press
- Number of pages
- 9
- Grant note
- University of Wisconsin UR3/CCU523235; UR3/DD000078 / Centers for Disease Control and Prevention, Cooperative; United States Department of Health & Human Services; Centers for Disease Control & Prevention - USA UR3DD000078 / CENTERS FOR DISEASE CONTROL AND PREVENTION; United States Department of Health & Human Services; Centers for Disease Control & Prevention - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000261279600006
- Scopus ID
- 2-s2.0-57149100947
- Other Identifier
- 991019169651504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health