Journal article
Advances in Cell Therapy for Neural Repair
The Journal of neuroscience, v 46(17), e1675252026
29 Apr 2026
PMID: 42055920
Abstract
Neural repair remains one of the foremost challenges in modern neuroscience, as damage to the central nervous system caused by injury or neurodegenerative disease often leads to irreversible loss of function. The advent and rapid evolution of utilizing stem cell biology have provided unprecedented opportunities to advance regenerative strategies aimed at restoring brain and spinal cord integrity, with the goal of regaining lost functions and improving outcomes for individuals living with injury and disease. Among these, cell therapies using derivatives of pluripotent stem cells have emerged as promising approaches, driving innovation from primary tissue transplants to the engineering of induced pluripotent stem cell-derived neuronal and glial progenitors and now to complex multicellular brain and spinal cord organoids. Complementing these biological innovations, artificial intelligence and machine learning are transforming regenerative neuroscience by enabling large-scale data analysis and predictive modeling. This review synthesizes recent progress across these areas, highlighting emerging technologies and therapeutic adjuncts that enhance the applicability and efficacy of neural repair paradigms.
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Details
- Title
- Advances in Cell Therapy for Neural Repair
- Creators
- Lyandysha V Zholudeva - Gladstone InstitutesSoshana P Svendsen - Cedars-Sinai Medical CenterIrene L Llorente - Palo Alto UniversityVanessa Kan - Palo Alto UniversityEve C Tsai - Ottawa HospitalVictor Ogbolu - Drexel UniversityLiang Qiang - Drexel UniversityEdward D Wirth, 3rd - Aspen Neuroscience, San Diego, California 92121Carlos A Paladini - Spero Therapeutics (United States)Clive N Svendsen - Cedars-Sinai Medical CenterMichael A Lane - Drexel University
- Publication Details
- The Journal of neuroscience, v 46(17), e1675252026
- Publisher
- Society for Neuroscience
- Number of pages
- 14
- Grant note
- Alzheimer's Association: 24AARG-D-1191264 BlueRock Therapeutics California Institute for Regenerative Medicine: DISC2-14180, DISC2-10714, DISC2-12169, TRAN1-12891, CLIN2-12319 Joan Johnston Family Foundation Lisa Dean Moseley Foundation National Institutes of Health: NINDS: R01 NS104291 NINDS: R01 NS115977 SPF Foundation Research Grant Stem Cell Network Impact Award University of Ottawa: Department of Surgery Research Grant, Department of Surgery, Faculty of Medicine
ALSfindingACure and Hop-on-a-Cure Funded Research Grant (L.Q.) . Alzheimer's Association Research Grant 24AARG-D-1191264 (L.Q.) . Aspen Neurosciences (E.D.W.) . BlueRock Therapeutics (C.A.P.) . California Institute for Regenerative Medicine DISC2-14180 (L.V.Z.) , DISC2-10714 (I.L.L.) , DISC2-12169 (I.L.L.) , TRAN1-12891 (I.L.L.) , CLIN2-12319 (C.N.S.) . Josette Robertson and Joan Johnston Family Foundation (E.C.T.) . Lisa Dean Moseley Foundation (M.A.L.) . National Institutes of Health: NINDS R01 NS104291 (M.A.L.) , NINDS R01 RNS103788A (I.L.L.) , NINDS R01 NS115977 (L.Q.) . SPF Foundation Research Grant (L.Q.) . Stem Cell Network Impact Award (E.C.T.) . University of Ottawa: Department of Surgery Research Grant, Department of Surgery, Faculty of Medicine (E.C.T.) .
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:001761114100002
- Scopus ID
- 2-s2.0-105037562706
- Other Identifier
- 991022176485704721