Journal article
Advances in Targeted and Systemic Therapy for Salivary Gland Carcinomas: Current Options and Future Directions
Current oncology (Toronto), v 32(4), 232
16 Apr 2025
PMID: 40277788
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Salivary gland carcinomas (SGCs) represent a rare and heterogeneous group of malignancies accounting for 3-6% of all head and neck cancers. While surgical resection and radiotherapy remain the standard for locoregional control, systemic treatment is indicated for recurrent or metastatic disease. Advances in molecular profiling have identified actionable targets such as NTRK gene fusions, HER2, immune checkpoint regulators, androgen receptors, and RET receptors. These have facilitated the development of targeted therapies, including TRK inhibitors, HER2-directed agents, and androgen receptor modulators, as well as emerging combinations of immunotherapy and chemotherapy. Despite these advancements, challenges such as resistance mechanisms and limited therapeutic efficacy persist. Overall response rates remain relatively low across most systemic therapies, reflecting a persistent unmet clinical need. This review discusses the current landscape of treatment options and explores promising clinical trials and future directions to enhance outcomes for patients with SGCs.
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Details
- Title
- Advances in Targeted and Systemic Therapy for Salivary Gland Carcinomas: Current Options and Future Directions
- Creators
- Sushanth Sreenivasan - Allegheny Health NetworkRahim A Jiwani - Allegheny Health NetworkRichard White - Allegheny Health NetworkVeli Bakalov - Allegheny Health NetworkRyan Moll - Allegheny Health NetworkJoseph Liput - Allegheny Health NetworkLarisa Greenberg - Allegheny Health Network
- Publication Details
- Current oncology (Toronto), v 32(4), 232
- Publisher
- MDPI
- Number of pages
- 25
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Web of Science ID
- WOS:001474371000001
- Scopus ID
- 2-s2.0-105003481473
- Other Identifier
- 991022048905604721
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- Web of Science research areas
- Oncology