Journal article
Advances in cancer biomarkers as applied to chemical exposures: the ras oncogene and p21 protein and pulmonary carcinogenesis
Journal of occupational medicine, v 33(9), pp 951-955
Sep 1991
PMID: 1744743
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Pulmonary carcinogenesis due to occupational and environmental exposures to chemical carcinogens such as polycyclic aromatic hydrocarbons presents an interesting model for study of possible oncogene-related cancer biomarkers. Polycyclic aromatic hydrocarbons are important respiratory carcinogens and have been shown to cause specific mutational lesions that can lead to the activation of the ras oncogene and expression of its p21 protein product; ras oncogene activation and p21 expression frequently are detected in human lung cancers. In addition, the p21 protein is detectable via immunoblotting techniques in the serum of lung cancer patients and in selected persons in exposed worker cohorts at risk for the development of lung cancer. Thus, the ras oncogene and p21 protein may be useful biomarkers for monitoring pulmonary carcinogenesis in exposed populations.
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Details
- Title
- Advances in cancer biomarkers as applied to chemical exposures: the ras oncogene and p21 protein and pulmonary carcinogenesis
- Creators
- P W Brandt-Rauf - Columbia University
- Publication Details
- Journal of occupational medicine, v 33(9), pp 951-955
- Grant note
- OH00076 / NIOSH CDC HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; Drexel University
- Web of Science ID
- WOS:A1991GE84900007
- Scopus ID
- 2-s2.0-0025942221
- Other Identifier
- 991019342615004721
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- Web of Science research areas
- Public, Environmental & Occupational Health