Journal article
Advances in studies of ncRNAs in the pathophysiology and treatment of spinal disease
General physiology and biophysics, v 41(1), pp 1-14
01 Jan 2022
PMID: 35253646
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Symptoms of spinal disease frequently accompany altered or damaged spine and vertebral structures resulting from endogenous and exogenous factors. Back braces, therapeutic agents, and surgery remain the main treatments for spinal diseases. However, the efficacy of currently available therapeutic agents is limited due to their side effects, whereas back braces and surgeries are less effective for certain patients. The significant effect of spinal disease on patients??? morbidity and mortality emphasizes the necessity to develop novel and more effective therapeutic agents that mitigate the consequences of spinal disease. Accumulating research acknowledges that non-coding RNAs (ncRNAs), including miRNAs, lncRNAs, circRNAs, etc., are involved in the pathogenesis of spinal disease, their pronounced therapeutic potential and significant regulatory functions in spinal diseases. Hence, this review focuses on summarizing the latest advances in studies of ncRNAs in the progression and recovery of spinal diseases, as well as highlighting the collaboration of ncRNA networks in treating spinal disease.
Metrics
12 Record Views
Details
- Title
- Advances in studies of ncRNAs in the pathophysiology and treatment of spinal disease
- Creators
- Jie Wang - Huangpu Dist Dapuqiao Community Hlth Ctr, Shanghai 200023, Peoples R ChinaWei Wei - Huangpu Dist Dapuqiao Community Hlth Ctr, Shanghai 200023, Peoples R ChinaYouji Jia - Shanghai Jiao Tong UniversityXiaobing Xi - Shanghai Jiao Tong UniversityYing Jin - Huangpu Dist Dapuqiao Community Hlth Ctr, Shanghai 200023, Peoples R China
- Publication Details
- General physiology and biophysics, v 41(1), pp 1-14
- Publisher
- Aepress Sro
- Number of pages
- 14
- Grant note
- Traditional Chinese Medicine Characteristic Health Service Station Construction Project of Huangpu District
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000821074200001
- Scopus ID
- 2-s2.0-85125842170
- Other Identifier
- 991020545222804721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemistry & Molecular Biology
- Biophysics
- Physiology