Journal article
Advances in vibrational spectroscopy as a sensitive probe of peptide and protein structure
Vibrational spectroscopy, v 42(1), pp 98-117
2006
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Over the last 40 years the theoretical basis has been developed for using vibrational spectroscopy as a tool for peptide and protein structure analysis. In spite of these efforts it is still considered to be a low-resolution technique, which cannot compete with NMR and X-ray crystallography. However, experimental and computational developments over the last 10 years have provided tools which make vibrational spectroscopy a much more powerful technique. This review focuses mostly, though not exclusively, on the use of the amide I mode for the structure analysis of polypeptides. It evaluates the physical basis of a variety of theoretical and experimental concepts and argues that only a combination of different techniques and spectroscopies can advance the field towards a more precise determination of dihedral angles in even highly heterogeneous polypeptides.
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Details
- Title
- Advances in vibrational spectroscopy as a sensitive probe of peptide and protein structure
- Creators
- Reinhard Schweitzer-Stenner - Department of Chemistry, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104, USA
- Publication Details
- Vibrational spectroscopy, v 42(1), pp 98-117
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Chemistry
- Web of Science ID
- WOS:000241719900016
- Scopus ID
- 2-s2.0-33749569009
- Other Identifier
- 991014878190104721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Chemistry, Analytical
- Chemistry, Physical
- Spectroscopy