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Journal article
Advancing β-adrenoreceptor agonism for recovery after volumetric muscle loss through regenerative rehabilitation and biomaterial delivery approaches
Regenerative biomaterials, v 12, rbaf015
01 Jan 2025
PMID: 40256211
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Volumetric muscle loss (VML) injury results in the unrecoverable loss of muscle mass and contractility. Oral delivery of formoterol, a beta 2-adrenergic receptor agonist, produces a modest recovery of muscle mass and contractility in VML-injured mice. The objective of this study was to determine if a regenerative rehabilitation paradigm or a regenerative medicine paradigm could enhance the recovery of VML-injured muscle. Regenerative rehabilitation involved oral formoterol delivery combined with voluntary wheel running. Regenerative medicine involved direct delivery of formoterol to VML-injured muscle using a non-biodegradable poly(ethylene glycol) biomaterial. To determine if the regenerative rehabilitation or regenerative medicine approaches were effective at 8 weeks post-injury, muscle mass, contractile function, metabolic function, and histological evaluations were used. One model of regenerative rehabilitation, in which rehabilitation was delayed until 1 month post-injury, resulted in greater muscle mass, muscle contractility, and permeabilized muscle fiber mitochondrial respiration compared to untreated VML-injured mice. Histologically, these mice had evidence of greater total muscle fiber number and oxidative fibers; however, they also had a greater percentage of densely packed collagen. The regenerative medicine model produced greater permeabilized muscle fiber mitochondrial respiration compared to untreated VML-injured mice; however, the non-biodegradable biomaterial was associated with fewer total muscle fibers and lower muscle quality (i.e. lower muscle mass-normalized contractility). The conclusions reached from this study are: (i) regenerative rehabilitation and regenerative medicine strategies utilizing formoterol require further optimization but showed promising outcomes; and (ii) in general, beta-adrenergic receptor agonism continues to be a physiologically supportive intervention to improve muscle contractile and metabolic function after VML injury.
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Details
- Title
- Advancing β-adrenoreceptor agonism for recovery after volumetric muscle loss through regenerative rehabilitation and biomaterial delivery approaches
- Creators
- Jennifer McFaline-Figueroa - University of GeorgiaChristiana J. Raymond-Pope - University of MinnesotaJoseph J. Pearson - The Wallace H. Coulter Department of Biomedical EngineeringAlbino G. Schifino - University of GeorgiaJunwon Heo - University of GeorgiaThomas J. Lillquist - University of MinnesotaEmma E. Pritchard - University of MinnesotaElizabeth A. Winders - University of GeorgiaEdward T. Hunda - University of GeorgiaJohnna S. Temenoff - The Wallace H. Coulter Department of Biomedical EngineeringSarah M. Greising - University of MinnesotaJarrod A. Call (Corresponding Author) - University of Georgia
- Publication Details
- Regenerative biomaterials, v 12, rbaf015
- Publisher
- Oxford University Press
- Number of pages
- 16
- Grant note
- SCR_020997 / Congressionally Directed Medical Research Program; United States Department of Defense
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Physical Therapy (and Rehabilitation Sciences)
- Web of Science ID
- WOS:001469388700001
- Scopus ID
- 2-s2.0-105003322531
- Other Identifier
- 991022052933804721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Materials Science, Biomaterials