Journal article
Advancing parental age and autism: multifactorial pathways
Trends in molecular medicine, v 21(2), pp 118-125
Feb 2015
PMID: 25662027
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Converging evidence from epidemiological, genetic, and animal studies supports the hypothesis that advancing parental age, both of the father and mother, increases the risk of autism spectrum disorders (ASD) in offspring. Paternal age has received considerable attention, with whole-genome sequencing studies linking older fathers to higher rates of de novo mutations and increased risk of ASD. The current evidence suggests that the increased risk of ASD in the offspring of older mothers may be related to mechanisms different from those operating in older fathers. Causal pathways probably involve the interaction of multiple risk factors. Although the etiology of ASD is still poorly understood, studies of parental age provide clues into the genetic and environ-mental mechanisms that mediate the risk of ASD.
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Details
- Title
- Advancing parental age and autism: multifactorial pathways
- Creators
- Brian K LeeJohn J McGrath
- Publication Details
- Trends in molecular medicine, v 21(2), pp 118-125
- Publisher
- Elsevier; England
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000349876700010
- Scopus ID
- 2-s2.0-84931201751
- Other Identifier
- 991014878479204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Cell Biology
- Medicine, Research & Experimental