Journal article
Advancing the hypothesis that geographic variations in risk factors contribute relatively little to observed geographic variations in heart disease and stroke mortality
Preventive medicine, v 49(2), pp 129-132
2009
PMID: 19285103
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Geographic variation in risk factors may underlie geographic disparities in coronary heart disease (CHD) and stroke mortality.
Framingham CHD Risk Score (FCRS) and Stroke Risk Score (FSRS) were calculated for 25,770 stroke-free and 22,247 CHD-free participants from the REasons for Geographic And Racial Differences in Stroke cohort. Vital statistics provided age-adjusted CHD and stroke mortality rates. In an ecologic analysis, the age-adjusted, race–sex weighted, average state-level risk factor levels were compared to state-level mortality rates.
There was no relationship between CHD and stroke mortality rates (
r
=
0.04;
p
=
0.78), but there was between CHD and stroke risk scores at the individual (
r
=
0.68;
p
<
0.0001) and state (
r
=
0.64,
p
<
0.0001) level. There was a stronger (
p
<
0.0001) association between state-level FCRS and state-level CHD mortality (
r
=
0.28,
p
=
0.18), than between FSRS and stroke mortality (
r
=
0.12,
p
=
0.56).
Weak associations between CHD and stroke mortality and strong associations between CHD and stroke risk scores suggest that geographic variation in risk factors may not underlie geographic variations in stroke and CHD mortality. The relationship between risk factor scores and mortality was stronger for CHD than stroke.
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Details
- Title
- Advancing the hypothesis that geographic variations in risk factors contribute relatively little to observed geographic variations in heart disease and stroke mortality
- Creators
- George Howard - University of Alabama at BirminghamMary Cushman - University of VermontRonald J. Prineas - Wake Forest UniversityVirginia J. Howard - University of Alabama at BirminghamClaudia S. Moy - National Institute of Neurological Disorders and StrokeLisa M. Sullivan - Framingham Heart StudyRalph B. D'Agostino - National Institute of Neurological Disorders and StrokeLeslie A. McClure - University of Alabama at BirminghamLeaVonne Pulley - Department of Health Behavior, University of Arkansas Health Science University, Little Rock, AK, USAMonika M. Safford - University of Alabama at Birmingham
- Publication Details
- Preventive medicine, v 49(2), pp 129-132
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Epidemiology and Biostatistics
- Web of Science ID
- WOS:000270562200011
- Scopus ID
- 2-s2.0-70349281707
- Other Identifier
- 991019231625704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health