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Adverse Effects of Long-Term Proton Pump Inhibitor Use: A Review for the Otolaryngologist
Journal article   Peer reviewed

Adverse Effects of Long-Term Proton Pump Inhibitor Use: A Review for the Otolaryngologist

D. Brandon Chapman, Catherine J. Rees, Dylan Lippert, Robert T. Sataloff and S. Carter Wright
Journal of voice, v 25(2), pp 236-240
2011
DOI: https://doi.org/10.1016/j.jvoice.2009.10.015
PMID: 20144536
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Antacid Complications of proton pump inhibitor Laryngopharyngeal reflux Proton pump inhibitor Reflux
Proton pump inhibitors (PPIs) are the mainstay of current medical management for laryngopharyngeal reflux, and treatment often involves long-term use of this class of medications. The long-term adverse effects of PPI use have not been studied extensively, but several analyses have demonstrated epidemiological links between PPI use and adverse outcomes. These include altered mineral and vitamin absorption, orthopedic injury, acute coronary syndromes (ACS), and infectious risks. A PubMed search was performed for subject headings, including PPIs and adverse outcomes. Relevant studies were included in this review. Studies were compiled, reviewed, and compared in a narrative form. Several epidemiological links between PPI use and metabolic, infectious, cardiac, and orthopedic adverse outcomes were found. No definite causal effects were identified. Given these epidemiological patterns, we recommend that the clinician be aware of these possible unintended consequences. In addition, we recommend consideration of dual-energy X-ray absorptiometry (DEXA) bone density scans in at-risk patients who have not been previously tested. We recommend consideration of vitamin B 12 and iron levels in selected patients who are at high risk. We also recommend close communication with our cardiology colleagues, as we attempt to ascertain the relationship between clopidogrel and PPI use. We recommend caution in the use of omeprazole in patients undergoing active treatment for ACS. Finally, we recommend consideration of Helicobacter pylori or serum gastrin level testing in patients with known risk factors for gastric carcinoma.

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9 Record Views
27 citations in Web of Science
29 citations in Scopus

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UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
Web of Science research areas
Audiology & Speech-language Pathology
Otorhinolaryngology
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