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Adverse effects of pentobarbital on cerebral venous oxygenation of comatose patients with acute traumatic brain swelling: relationship to outcome
Journal article   Peer reviewed

Adverse effects of pentobarbital on cerebral venous oxygenation of comatose patients with acute traumatic brain swelling: relationship to outcome

Julio Cruz and Janet Cruz
Journal of neurosurgery, v 85(5), pp 758-761
Nov 1996
DOI: https://doi.org/10.3171/jns.1996.85.5.0758
PMID: 8893711
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

✓ Global cerebrovenous oxygenation was evaluated before and after intravenous administration of pentobarbital sodium for the management of refractory intracranial hypertension in 151 comatose patients who had acute traumatic brain swelling. Two groups of patients were identified: a group in which the jugular oxyhemoglobin saturation (SjO 2 ) remained at or above 45% after pentobarbital bolus, and a group in which the SjO 2 dropped below 45%. The two groups were matched by predominant findings on computerized tomography scans of the head, as well as age, postresuscitation Glasgow Coma Scale scores, levels of total hemoglobin content, SjO 2 , intracranial pressure (ICP), and cerebral perfusion pressure (CPP) prior to pentobarbital bolus. Outcomes were significantly worse (p < 0.0001) in patients who developed decreases in SjO 2 to levels below 45% than in those whose SjO 2 remained at or above 45%, despite the fact that there were no significant differences between the two groups with regard to ICP and CPP after an intravenous bolus of pentobarbital.

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57 citations in Web of Science
73 citations in Scopus

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Web of Science research areas
Clinical Neurology
Surgery
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