Journal article
Affinity-purified CCAAT-box-binding protein (YEBP) functionally regulates expression of a human class II major histocompatibility complex gene and the herpes simplex virus thymidine kinase gene
Proceedings of the National Academy of Sciences - PNAS, v 88(5), pp 1873-1877
01 Mar 1991
PMID: 1848012
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Efficient major histocompatibility complex class II gene expression requires conserved protein-binding promoter elements, including X and Y elements. We affinity purified an HLA-DRA Y-element (CCAAT)-binding protein (YEBP) and used it to reconstitute Y-depleted HLA-DRA in vitro transcription. This directly demonstrates a positive functional role for YEBP in HLA-DRA transcription. The ability of YEBP to regulate divergent CCAAT elements was also assessed; YEBP was found to partially activate the thymidine kinase promoter. This functional analysis of YEBP shows that this protein plays an important role in the regulation of multiple genes.
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Details
- Title
- Affinity-purified CCAAT-box-binding protein (YEBP) functionally regulates expression of a human class II major histocompatibility complex gene and the herpes simplex virus thymidine kinase gene
- Creators
- N J Zeleznik-Le - University of North Carolina at Chapel HillJ C Azizkhan - University of North CarolinaJ P Ting - Lineberger Comprehensive Cancer Center
- Publication Details
- Proceedings of the National Academy of Sciences - PNAS, v 88(5), pp 1873-1877
- Publisher
- PNAS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:A1991FA14000059
- Scopus ID
- 2-s2.0-0026081823
- Other Identifier
- 991020200888904721
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- Web of Science research areas
- Biochemistry & Molecular Biology